Splicing of long non-coding RNAs primarily depends on polypyrimidine tract and 5′ splice-site sequences due to weak interactions with SR proteins

Many nascent long non-coding RNAs (lncRNAs) undergo the same maturation steps as pre-mRNAs of protein-coding genes (PCGs), but they are often poorly spliced. To identify the underlying mechanisms for this phenomenon, we searched for putative splicing inhibitory sequences using the ncRNA-a2 as a mode...

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Detalles Bibliográficos
Autores principales: Krchňáková, Zuzana, Thakur, Prasoon Kumar, Krausová, Michaela, Bieberstein, Nicole, Haberman, Nejc, Müller-McNicoll, Michaela, Staněk, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344860/
https://www.ncbi.nlm.nih.gov/pubmed/30445574
http://dx.doi.org/10.1093/nar/gky1147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344860/
https://www.ncbi.nlm.nih.gov/pubmed/30445574
http://dx.doi.org/10.1093/nar/gky1147

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