Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1)

Cancer-associated mutations of the core splicing factor 3 B1 (SF3B1) result in selection of novel 3′ splice sites (3′SS), but precise molecular mechanisms of oncogenesis remain unclear. SF3B1 stabilizes the interaction between U2 snRNP and branch point (BP) on the pre-mRNA. It has hence been specula...

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Detalles Bibliográficos
Autores principales: Gupta, Abhishek K, Murthy, Tushar, Paul, Kiran V, Ramirez, Oscar, Fisher, Joseph B, Rao, Sridhar, Rosenberg, Alexander B, Seelig, Georg, Minella, Alex C, Pillai, Manoj M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344872/
https://www.ncbi.nlm.nih.gov/pubmed/30462273
http://dx.doi.org/10.1093/nar/gky1161

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