Single and double box HMGB proteins differentially destabilize nucleosomes

Nucleosome disruption plays a key role in many nuclear processes including transcription, DNA repair and recombination. Here we combine atomic force microscopy (AFM) and optical tweezers (OT) experiments to show that high mobility group B (HMGB) proteins strongly disrupt nucleosomes, revealing a new...

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Detalles Bibliográficos
Autores principales: McCauley, Micah J, Huo, Ran, Becker, Nicole, Holte, Molly Nelson, Muthurajan, Uma M, Rouzina, Ioulia, Luger, Karolin, Maher, L James, Israeloff, Nathan E, Williams, Mark C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344895/
https://www.ncbi.nlm.nih.gov/pubmed/30445475
http://dx.doi.org/10.1093/nar/gky1119

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