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Applications of mesenchymal stem cell technology in bovine species

Mesenchymal stem cells (MSCs) have received a great deal of attention over the past 20 years mainly because of the results that showed regeneration potential and plasticity that were much stronger than expected in prior decades. Recent findings in this field have contributed to progress in the estab...

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Autores principales: Hill, Amanda Baracho Trindade, Bressan, Fabiana Fernandes, Murphy, Bruce D., Garcia, Joaquim Mansano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345009/
https://www.ncbi.nlm.nih.gov/pubmed/30678726
http://dx.doi.org/10.1186/s13287-019-1145-9
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author Hill, Amanda Baracho Trindade
Bressan, Fabiana Fernandes
Murphy, Bruce D.
Garcia, Joaquim Mansano
author_facet Hill, Amanda Baracho Trindade
Bressan, Fabiana Fernandes
Murphy, Bruce D.
Garcia, Joaquim Mansano
author_sort Hill, Amanda Baracho Trindade
collection PubMed
description Mesenchymal stem cells (MSCs) have received a great deal of attention over the past 20 years mainly because of the results that showed regeneration potential and plasticity that were much stronger than expected in prior decades. Recent findings in this field have contributed to progress in the establishment of cell differentiation methods, which have made stem cell therapy more clinically attractive. In addition, MSCs are easy to isolate and have anti-inflammatory and angiogenic capabilities. The use of stem cell therapy is currently supported by scientific literature in the treatment of several animal health conditions. MSC may be administered for autologous or allogenic therapy following either a fresh isolation or a thawing of a previously frozen culture. Despite the fact that MSCs have been widely used for the treatment of companion and sport animals, little is known about their clinical and biotechnological potential in the economically relevant livestock industry. This review focuses on describing the key characteristics of potential applications of MSC therapy in livestock production and explores the themes such as the concept, culture, and characterization of mesenchymal stem cells; bovine mesenchymal stem cell isolation; applications and perspectives on commercial interests and farm relevance of MSC in bovine species; and applications in translational research.
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spelling pubmed-63450092019-01-29 Applications of mesenchymal stem cell technology in bovine species Hill, Amanda Baracho Trindade Bressan, Fabiana Fernandes Murphy, Bruce D. Garcia, Joaquim Mansano Stem Cell Res Ther Review Mesenchymal stem cells (MSCs) have received a great deal of attention over the past 20 years mainly because of the results that showed regeneration potential and plasticity that were much stronger than expected in prior decades. Recent findings in this field have contributed to progress in the establishment of cell differentiation methods, which have made stem cell therapy more clinically attractive. In addition, MSCs are easy to isolate and have anti-inflammatory and angiogenic capabilities. The use of stem cell therapy is currently supported by scientific literature in the treatment of several animal health conditions. MSC may be administered for autologous or allogenic therapy following either a fresh isolation or a thawing of a previously frozen culture. Despite the fact that MSCs have been widely used for the treatment of companion and sport animals, little is known about their clinical and biotechnological potential in the economically relevant livestock industry. This review focuses on describing the key characteristics of potential applications of MSC therapy in livestock production and explores the themes such as the concept, culture, and characterization of mesenchymal stem cells; bovine mesenchymal stem cell isolation; applications and perspectives on commercial interests and farm relevance of MSC in bovine species; and applications in translational research. BioMed Central 2019-01-24 /pmc/articles/PMC6345009/ /pubmed/30678726 http://dx.doi.org/10.1186/s13287-019-1145-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Hill, Amanda Baracho Trindade
Bressan, Fabiana Fernandes
Murphy, Bruce D.
Garcia, Joaquim Mansano
Applications of mesenchymal stem cell technology in bovine species
title Applications of mesenchymal stem cell technology in bovine species
title_full Applications of mesenchymal stem cell technology in bovine species
title_fullStr Applications of mesenchymal stem cell technology in bovine species
title_full_unstemmed Applications of mesenchymal stem cell technology in bovine species
title_short Applications of mesenchymal stem cell technology in bovine species
title_sort applications of mesenchymal stem cell technology in bovine species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345009/
https://www.ncbi.nlm.nih.gov/pubmed/30678726
http://dx.doi.org/10.1186/s13287-019-1145-9
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