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11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study

BACKGROUND: A comparative study of 11 β HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted. METHODS: A case control experimental study was performed enrolling thirty type 2 diabetes mellitus patients and thirty age,...

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Detalles Bibliográficos
Autores principales: Shukla, Ravindra, Basu, Asish Kumar, Mandal, Biplab, Mukhopadhyay, Pradip, Maity, Animesh, Chakraborty, Satyam, Devrabhai, Praveen Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345010/
https://www.ncbi.nlm.nih.gov/pubmed/30678666
http://dx.doi.org/10.1186/s12902-019-0344-9
Descripción
Sumario:BACKGROUND: A comparative study of 11 β HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted. METHODS: A case control experimental study was performed enrolling thirty type 2 diabetes mellitus patients and thirty age, gender and BMI matched controls using cortisone acetate test. RESULTS: The rise of serum cortisol after oral 25 mg cortisone acetate from baseline (dexamethasone suppressed level) is higher in subjects with type 2 diabetes and is associated with exercise, BMI, SGOT but not daily calorie intake, lipid parameters and thyroid status. Fasting blood glucose after overnight 1 mg oral dexamethasone is a strong predictor of 11HSD1 activity, irrespective of presence of type 2 diabetes. CONCLUSION: 11β HSD 1 activity is higher in type 2 diabetes mellitus subjects, especially those who are lean. Future 11 β HSD 1 inhibitors targeting metabolic syndrome, will be most useful in those with increased fasting blood glucose. The role of DHEAS and vitamin D status needs to be explored. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12902-019-0344-9) contains supplementary material, which is available to authorized users.