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11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study

BACKGROUND: A comparative study of 11 β HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted. METHODS: A case control experimental study was performed enrolling thirty type 2 diabetes mellitus patients and thirty age,...

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Autores principales: Shukla, Ravindra, Basu, Asish Kumar, Mandal, Biplab, Mukhopadhyay, Pradip, Maity, Animesh, Chakraborty, Satyam, Devrabhai, Praveen Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345010/
https://www.ncbi.nlm.nih.gov/pubmed/30678666
http://dx.doi.org/10.1186/s12902-019-0344-9
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author Shukla, Ravindra
Basu, Asish Kumar
Mandal, Biplab
Mukhopadhyay, Pradip
Maity, Animesh
Chakraborty, Satyam
Devrabhai, Praveen Kumar
author_facet Shukla, Ravindra
Basu, Asish Kumar
Mandal, Biplab
Mukhopadhyay, Pradip
Maity, Animesh
Chakraborty, Satyam
Devrabhai, Praveen Kumar
author_sort Shukla, Ravindra
collection PubMed
description BACKGROUND: A comparative study of 11 β HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted. METHODS: A case control experimental study was performed enrolling thirty type 2 diabetes mellitus patients and thirty age, gender and BMI matched controls using cortisone acetate test. RESULTS: The rise of serum cortisol after oral 25 mg cortisone acetate from baseline (dexamethasone suppressed level) is higher in subjects with type 2 diabetes and is associated with exercise, BMI, SGOT but not daily calorie intake, lipid parameters and thyroid status. Fasting blood glucose after overnight 1 mg oral dexamethasone is a strong predictor of 11HSD1 activity, irrespective of presence of type 2 diabetes. CONCLUSION: 11β HSD 1 activity is higher in type 2 diabetes mellitus subjects, especially those who are lean. Future 11 β HSD 1 inhibitors targeting metabolic syndrome, will be most useful in those with increased fasting blood glucose. The role of DHEAS and vitamin D status needs to be explored. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12902-019-0344-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-63450102019-01-29 11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study Shukla, Ravindra Basu, Asish Kumar Mandal, Biplab Mukhopadhyay, Pradip Maity, Animesh Chakraborty, Satyam Devrabhai, Praveen Kumar BMC Endocr Disord Research Article BACKGROUND: A comparative study of 11 β HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted. METHODS: A case control experimental study was performed enrolling thirty type 2 diabetes mellitus patients and thirty age, gender and BMI matched controls using cortisone acetate test. RESULTS: The rise of serum cortisol after oral 25 mg cortisone acetate from baseline (dexamethasone suppressed level) is higher in subjects with type 2 diabetes and is associated with exercise, BMI, SGOT but not daily calorie intake, lipid parameters and thyroid status. Fasting blood glucose after overnight 1 mg oral dexamethasone is a strong predictor of 11HSD1 activity, irrespective of presence of type 2 diabetes. CONCLUSION: 11β HSD 1 activity is higher in type 2 diabetes mellitus subjects, especially those who are lean. Future 11 β HSD 1 inhibitors targeting metabolic syndrome, will be most useful in those with increased fasting blood glucose. The role of DHEAS and vitamin D status needs to be explored. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12902-019-0344-9) contains supplementary material, which is available to authorized users. BioMed Central 2019-01-24 /pmc/articles/PMC6345010/ /pubmed/30678666 http://dx.doi.org/10.1186/s12902-019-0344-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Shukla, Ravindra
Basu, Asish Kumar
Mandal, Biplab
Mukhopadhyay, Pradip
Maity, Animesh
Chakraborty, Satyam
Devrabhai, Praveen Kumar
11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study
title 11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study
title_full 11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study
title_fullStr 11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study
title_full_unstemmed 11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study
title_short 11β Hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study
title_sort 11β hydroxysteroid dehydrogenase – 1 activity in type 2 diabetes mellitus: a comparative study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345010/
https://www.ncbi.nlm.nih.gov/pubmed/30678666
http://dx.doi.org/10.1186/s12902-019-0344-9
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