Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

BACKGROUND: Due to the lack of effective therapies and poor prognosis in TNBC (triple-negative breast cancer) patients, there is a strong need to develop effective novel targeted therapies for this subtype of breast cancer. Inhibition of heat shock protein 90 (HSP90), a conserved molecular chaperone...

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Detalles Bibliográficos
Autores principales: Mumin, Nuramalina H., Drobnitzky, Neele, Patel, Agata, Lourenco, Luiza Madia, Cahill, Fiona F., Jiang, Yanyan, Kong, Anthony, Ryan, Anderson J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345040/
https://www.ncbi.nlm.nih.gov/pubmed/30678647
http://dx.doi.org/10.1186/s12885-019-5295-z

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