Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Pathogenic mutations in the tau gene (microtubule associated protein tau, MAPT) are linked to the onset of tauopathy, but the A152T variant is unique in acting as a risk factor for a range of disorders including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneratio...

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Detalles Bibliográficos
Autores principales: Carlomagno, Yari, Chung, Dah-eun Chloe, Yue, Mei, Kurti, Aishe, Avendano, Nicole M., Castanedes-Casey, Monica, Hinkle, Kelly M., Jansen-West, Karen, Daughrity, Lillian M., Tong, Jimei, Phillips, Virginia, Rademakers, Rosa, DeTure, Michael, Fryer, John D., Dickson, Dennis W., Petrucelli, Leonard, Cook, Casey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345061/
https://www.ncbi.nlm.nih.gov/pubmed/30674342
http://dx.doi.org/10.1186/s40478-019-0661-2

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