A synthetic approach to ‘click’ neoglycoprotein analogues of EPO employing one-pot native chemical ligation and CuAAC chemistry

The clinical significance of batch-wise variability on the pharmacokinetics and potency of commercial erythropoietin (EPO), prepared recombinantly as a heterogeneous mixture of glycoforms, necessitates the development of synthetic strategies to afford homogenous EPO formulations. Herein we present a...

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Detalles Bibliográficos
Autores principales: Lee, D. J., Cameron, A. J., Wright, T. H., Harris, P. W. R., Brimble, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345360/
https://www.ncbi.nlm.nih.gov/pubmed/30774876
http://dx.doi.org/10.1039/c8sc03409e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345360/
https://www.ncbi.nlm.nih.gov/pubmed/30774876
http://dx.doi.org/10.1039/c8sc03409e

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