The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma

Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis. FXR, a member of the metabolic nuclear receptor family, is markedly down-regulated in human CCA. Our aim was to evaluat...

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Detalles Bibliográficos
Autores principales: Di Matteo, S., Nevi, L., Costantini, D., Overi, D., Carpino, G., Safarikia, S., Giulitti, F., Napoletano, C., Manzi, E., De Rose, A. M., Melandro, F., Bragazzi, M., Berloco, P. B., Giuliante, F., Grazi, G., Giorgi, A., Cardinale, V., Adorini, L., Gaudio, E., Alvaro, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345424/
https://www.ncbi.nlm.nih.gov/pubmed/30677052
http://dx.doi.org/10.1371/journal.pone.0210077

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