Deletion of the p16(INK4a) tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate

The tumor suppressor p16(Ink4a), encoded by the INK4a gene, is an inhibitor of cyclin D-dependent kinases 4 and 6, CDK4 and CDK6. This inhibition prevents the phosphorylation of the retinoblastoma protein (pRb), resulting in cellular senescence through inhibition of E2F-mediated transcription of S p...

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Detalles Bibliográficos
Autores principales: Lee, Dong-Hong, Yu, Eun-Jeong, Aldahl, Joseph, Yang, Julie, He, Yongfeng, Hooker, Erika, Le, Vien, Mi, Jiaqi, Olson, Adam, Wu, Huiqing, Geradts, Joseph, Xiao, Guang Q., Gonzalgo, Mark L., Cardiff, Robert D., Sun, Zijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345450/
https://www.ncbi.nlm.nih.gov/pubmed/30677079
http://dx.doi.org/10.1371/journal.pone.0211153

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