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Estimation of auditory steady-state responses based on the averaging of independent EEG epochs
The amplitude of auditory steady-state responses (ASSRs) generated in the brainstem of rats exponentially decreases over the sequential averaging of EEG epochs. This behavior is partially due to the adaptation of the ASSR induced by the continuous and monotonous stimulation. In this study, we analyz...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345467/ https://www.ncbi.nlm.nih.gov/pubmed/30677031 http://dx.doi.org/10.1371/journal.pone.0206018 |
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author | Prado-Gutierrez, Pavel Martínez-Montes, Eduardo Weinstein, Alejandro Zañartu, Matías |
author_facet | Prado-Gutierrez, Pavel Martínez-Montes, Eduardo Weinstein, Alejandro Zañartu, Matías |
author_sort | Prado-Gutierrez, Pavel |
collection | PubMed |
description | The amplitude of auditory steady-state responses (ASSRs) generated in the brainstem of rats exponentially decreases over the sequential averaging of EEG epochs. This behavior is partially due to the adaptation of the ASSR induced by the continuous and monotonous stimulation. In this study, we analyzed the potential clinical relevance of the ASSR adaptation. ASSR were elicited in eight anesthetized adult rats by 8-kHz tones, modulated in amplitude at 115 Hz. We called independent epochs to those EEG epochs acquired with sufficiently long inter-stimulus interval, so the ASSR contained in any given epoch is not affected by the previous stimulation. We tested whether the detection of ASSRs is improved when the response is computed by averaging independent EEG epochs, containing only unadapted auditory responses. The improvements in the ASSR detection obtained with standard, weighted and sorted averaging were compared. In the absence of artifacts, when the ASSR was elicited by continuous acoustic stimulation, the computation of the ASSR amplitude relied upon the averaging method. While the adaptive behavior of the ASSR was still evident after the weighting of epochs, the sorted averaging resulted in under-estimations of the ASSR amplitude. In the absence of artifacts, the ASSR amplitudes computed by averaging independent epochs did not depend on the averaging procedure. Averaging independent epochs resulted in higher ASSR amplitudes and halved the number of EEG epochs needed to be acquired to achieve the maximum detection rate of the ASSR. Acquisition protocols based on averaging independent EEG epochs, in combination with appropriate averaging methods for artifact reduction might contribute to develop more accurate hearing assessments based on ASSRs. |
format | Online Article Text |
id | pubmed-6345467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63454672019-02-02 Estimation of auditory steady-state responses based on the averaging of independent EEG epochs Prado-Gutierrez, Pavel Martínez-Montes, Eduardo Weinstein, Alejandro Zañartu, Matías PLoS One Research Article The amplitude of auditory steady-state responses (ASSRs) generated in the brainstem of rats exponentially decreases over the sequential averaging of EEG epochs. This behavior is partially due to the adaptation of the ASSR induced by the continuous and monotonous stimulation. In this study, we analyzed the potential clinical relevance of the ASSR adaptation. ASSR were elicited in eight anesthetized adult rats by 8-kHz tones, modulated in amplitude at 115 Hz. We called independent epochs to those EEG epochs acquired with sufficiently long inter-stimulus interval, so the ASSR contained in any given epoch is not affected by the previous stimulation. We tested whether the detection of ASSRs is improved when the response is computed by averaging independent EEG epochs, containing only unadapted auditory responses. The improvements in the ASSR detection obtained with standard, weighted and sorted averaging were compared. In the absence of artifacts, when the ASSR was elicited by continuous acoustic stimulation, the computation of the ASSR amplitude relied upon the averaging method. While the adaptive behavior of the ASSR was still evident after the weighting of epochs, the sorted averaging resulted in under-estimations of the ASSR amplitude. In the absence of artifacts, the ASSR amplitudes computed by averaging independent epochs did not depend on the averaging procedure. Averaging independent epochs resulted in higher ASSR amplitudes and halved the number of EEG epochs needed to be acquired to achieve the maximum detection rate of the ASSR. Acquisition protocols based on averaging independent EEG epochs, in combination with appropriate averaging methods for artifact reduction might contribute to develop more accurate hearing assessments based on ASSRs. Public Library of Science 2019-01-24 /pmc/articles/PMC6345467/ /pubmed/30677031 http://dx.doi.org/10.1371/journal.pone.0206018 Text en © 2019 Prado-Gutierrez et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Prado-Gutierrez, Pavel Martínez-Montes, Eduardo Weinstein, Alejandro Zañartu, Matías Estimation of auditory steady-state responses based on the averaging of independent EEG epochs |
title | Estimation of auditory steady-state responses based on the averaging of independent EEG epochs |
title_full | Estimation of auditory steady-state responses based on the averaging of independent EEG epochs |
title_fullStr | Estimation of auditory steady-state responses based on the averaging of independent EEG epochs |
title_full_unstemmed | Estimation of auditory steady-state responses based on the averaging of independent EEG epochs |
title_short | Estimation of auditory steady-state responses based on the averaging of independent EEG epochs |
title_sort | estimation of auditory steady-state responses based on the averaging of independent eeg epochs |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345467/ https://www.ncbi.nlm.nih.gov/pubmed/30677031 http://dx.doi.org/10.1371/journal.pone.0206018 |
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