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Development of Highly Sensitive Biosensors of RAF Dimerization in Cells
The BRAF inhibitors dabrafenib and vemurafenib induce remarkable clinical responses in patients with BRAF-mutated melanomas. However, adverse events, including the emergence of secondary tumors and drug resistance, have been reported. Studies have revealed that undesirable RAF dimerization induced b...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345758/ https://www.ncbi.nlm.nih.gov/pubmed/30679688 http://dx.doi.org/10.1038/s41598-018-37213-2 |