Analogues of ERβ ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis

Pharmaceutical agents currently approved for the treatment of multiple sclerosis reduce relapse rates, but do not reverse or prevent neurodegeneration nor initiate myelin repair. The highly selective estrogen receptor (ER) β ligand chloroindazole (IndCl) shows particular promise promoting both remye...

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Detalles Bibliográficos
Autores principales: Karim, Hawra, Kim, Sung Hoon, Lauderdale, Kelli, Lapato, Andrew S., Atkinson, Kelley, Yasui, Norio, Yamate-Morgan, Hana, Sekyi, Maria, Katzenellenbogen, John A., Tiwari-Woodruff, Seema K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345788/
https://www.ncbi.nlm.nih.gov/pubmed/30679747
http://dx.doi.org/10.1038/s41598-018-37420-x

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