Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery

Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used a self-assembling peptidic nanoparticle (NP)...

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Detalles Bibliográficos
Autores principales: Yan, Huimin, Duan, Xin, Pan, Hua, Akk, Antonina, Sandell, Linda J., Wickline, Samuel A., Rai, Muhammad Farooq, Pham, Christine T. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345850/
https://www.ncbi.nlm.nih.gov/pubmed/30679644
http://dx.doi.org/10.1038/s41598-018-37018-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345850/
https://www.ncbi.nlm.nih.gov/pubmed/30679644
http://dx.doi.org/10.1038/s41598-018-37018-3

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