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Can enzyme proximity accelerate cascade reactions?

The last decade has seen an exponential expansion of interest in conjugating multiple enzymes of cascades in close proximity to each other, with the overarching goal being to accelerate the overall reaction rate. However, some evidence has emerged that there is no effect of proximity channeling on t...

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Detalles Bibliográficos
Autores principales: Kuzmak, Andrij, Carmali, Sheiliza, von Lieres, Eric, Russell, Alan J., Kondrat, Svyatoslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345930/
https://www.ncbi.nlm.nih.gov/pubmed/30679600
http://dx.doi.org/10.1038/s41598-018-37034-3

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