IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy. Here, we report that an IRE1α RNase-specific inhibitor, MKC8866,...

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Detalles Bibliográficos
Autores principales: Sheng, Xia, Nenseth, Hatice Zeynep, Qu, Su, Kuzu, Omer F., Frahnow, Turid, Simon, Lukas, Greene, Stephanie, Zeng, Qingping, Fazli, Ladan, Rennie, Paul S., Mills, Ian G., Danielsen, Håvard, Theis, Fabian, Patterson, John B., Jin, Yang, Saatcioglu, Fahri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345973/
https://www.ncbi.nlm.nih.gov/pubmed/30679434
http://dx.doi.org/10.1038/s41467-018-08152-3

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