Sensitive Molybdenum Disulfide Based Field Effect Transistor Sensor for Real-time Monitoring of Hydrogen Peroxide

A reliable and highly sensitive hydrogen peroxide (H(2)O(2)) field effect transistor (FET) sensor is reported, which was constructed by using molybdenum disulfide (MoS(2))/reduced graphene oxide (RGO). In this work, we prepared MoS(2) nanosheets by a simple liquid ultrasonication exfoliation method. After the RGO-based FET device was fabricated, MoS(2) was assembled onto the RGO surface for constructing MoS(2)/RGO FET sensor. The as-prepared FET sensor showed an ultrahigh sensitivity and fast response toward H(2)O(2) in a real-time monitoring manner with a limit of detection down to 1 pM. In addition, the constructed sensor also exhibited a high specificity toward H(2)O(2) in complex biological matrix. More importantly, this novel biosensor was capable of monitoring of H(2)O(2) released from HeLa cells in real-time. So far, this is the first report of MoS(2)/RGO based FET sensor for electrical detection of signal molecules directly from cancer cells. Hence it is promising as a new platform for the clinical diagnosis of H(2)O(2)-related diseases.