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Polygenic impact of common genetic risk loci for Alzheimer’s disease on cerebral blood flow in young individuals

Genome-wide association studies (GWAS) show that many common alleles confer risk for developing Alzheimer’s disease (AD). These risk loci may contribute to MRI alterations in young individuals, preceding the clinical manifestations of AD. Prior evidence identifies vascular dysregulation as the earli...

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Detalles Bibliográficos
Autores principales:	Chandler, Hannah L., Wise, Richard G., Murphy, Kevin, Tansey, Katherine E., Linden, David E. J., Lancaster, Thomas M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345995/ https://www.ncbi.nlm.nih.gov/pubmed/30679549 http://dx.doi.org/10.1038/s41598-018-36820-3

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