Arrestin-1 engineering facilitates complex stabilization with native rhodopsin

Arrestin-1 desensitizes the activated and phosphorylated photoreceptor rhodopsin by forming transient rhodopsin−arrestin-1 complexes that eventually decay to opsin, retinal and arrestin-1. Via a multi-dimensional screening setup, we identified and combined arrestin-1 mutants that form lasting comple...

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Detalles Bibliográficos
Autores principales: Haider, Raphael S., Wilhelm, Florian, Rizk, Aurélien, Mutt, Eshita, Deupi, Xavier, Peterhans, Christian, Mühle, Jonas, Berger, Philipp, Schertler, Gebhard F. X., Standfuss, Jörg, Ostermaier, Martin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346018/
https://www.ncbi.nlm.nih.gov/pubmed/30679635
http://dx.doi.org/10.1038/s41598-018-36881-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346018/
https://www.ncbi.nlm.nih.gov/pubmed/30679635
http://dx.doi.org/10.1038/s41598-018-36881-4

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