Cargando…

Regulation of volatile and non-volatile pheromone attractants depends upon male social status

We investigated the regulation of chemical signals of house mice living in seminatural social conditions. We found that male mice more than doubled the excretion of major urinary proteins (MUPs) after they acquired a territory and become socially dominant. MUPs bind and stabilize the release of vola...

Descripción completa

Detalles Bibliográficos
Autores principales: Thoß, M., Luzynski, K. C., Enk, V. M., Razzazi-Fazeli, E., Kwak, J., Ortner, I., Penn, D. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346026/
https://www.ncbi.nlm.nih.gov/pubmed/30679546
http://dx.doi.org/10.1038/s41598-018-36887-y
_version_ 1783389682575343616
author Thoß, M.
Luzynski, K. C.
Enk, V. M.
Razzazi-Fazeli, E.
Kwak, J.
Ortner, I.
Penn, D. J.
author_facet Thoß, M.
Luzynski, K. C.
Enk, V. M.
Razzazi-Fazeli, E.
Kwak, J.
Ortner, I.
Penn, D. J.
author_sort Thoß, M.
collection PubMed
description We investigated the regulation of chemical signals of house mice living in seminatural social conditions. We found that male mice more than doubled the excretion of major urinary proteins (MUPs) after they acquired a territory and become socially dominant. MUPs bind and stabilize the release of volatile pheromone ligands, and some MUPs exhibit pheromonal properties themselves. We conducted olfactory assays and found that female mice were more attracted to the scent of dominant than subordinate males when they were in estrus. Yet, when male status was controlled, females were not attracted to urine with high MUP concentration, despite being comparable to levels of dominant males. To determine which compounds influence female attraction, we conducted additional analyses and found that dominant males differentially upregulated the excretion of particular MUPs, including the pheromone MUP20 (darcin), and a volatile pheromone that influences female reproductive physiology and behavior. Our findings show that once male house mice become territorial and socially dominant, they upregulate the amount and types of excreted MUPs, which increases the intensities of volatiles and the attractiveness of their urinary scent to sexually receptive females.
format Online
Article
Text
id pubmed-6346026
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-63460262019-01-29 Regulation of volatile and non-volatile pheromone attractants depends upon male social status Thoß, M. Luzynski, K. C. Enk, V. M. Razzazi-Fazeli, E. Kwak, J. Ortner, I. Penn, D. J. Sci Rep Article We investigated the regulation of chemical signals of house mice living in seminatural social conditions. We found that male mice more than doubled the excretion of major urinary proteins (MUPs) after they acquired a territory and become socially dominant. MUPs bind and stabilize the release of volatile pheromone ligands, and some MUPs exhibit pheromonal properties themselves. We conducted olfactory assays and found that female mice were more attracted to the scent of dominant than subordinate males when they were in estrus. Yet, when male status was controlled, females were not attracted to urine with high MUP concentration, despite being comparable to levels of dominant males. To determine which compounds influence female attraction, we conducted additional analyses and found that dominant males differentially upregulated the excretion of particular MUPs, including the pheromone MUP20 (darcin), and a volatile pheromone that influences female reproductive physiology and behavior. Our findings show that once male house mice become territorial and socially dominant, they upregulate the amount and types of excreted MUPs, which increases the intensities of volatiles and the attractiveness of their urinary scent to sexually receptive females. Nature Publishing Group UK 2019-01-24 /pmc/articles/PMC6346026/ /pubmed/30679546 http://dx.doi.org/10.1038/s41598-018-36887-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Thoß, M.
Luzynski, K. C.
Enk, V. M.
Razzazi-Fazeli, E.
Kwak, J.
Ortner, I.
Penn, D. J.
Regulation of volatile and non-volatile pheromone attractants depends upon male social status
title Regulation of volatile and non-volatile pheromone attractants depends upon male social status
title_full Regulation of volatile and non-volatile pheromone attractants depends upon male social status
title_fullStr Regulation of volatile and non-volatile pheromone attractants depends upon male social status
title_full_unstemmed Regulation of volatile and non-volatile pheromone attractants depends upon male social status
title_short Regulation of volatile and non-volatile pheromone attractants depends upon male social status
title_sort regulation of volatile and non-volatile pheromone attractants depends upon male social status
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346026/
https://www.ncbi.nlm.nih.gov/pubmed/30679546
http://dx.doi.org/10.1038/s41598-018-36887-y
work_keys_str_mv AT thoßm regulationofvolatileandnonvolatilepheromoneattractantsdependsuponmalesocialstatus
AT luzynskikc regulationofvolatileandnonvolatilepheromoneattractantsdependsuponmalesocialstatus
AT enkvm regulationofvolatileandnonvolatilepheromoneattractantsdependsuponmalesocialstatus
AT razzazifazelie regulationofvolatileandnonvolatilepheromoneattractantsdependsuponmalesocialstatus
AT kwakj regulationofvolatileandnonvolatilepheromoneattractantsdependsuponmalesocialstatus
AT ortneri regulationofvolatileandnonvolatilepheromoneattractantsdependsuponmalesocialstatus
AT penndj regulationofvolatileandnonvolatilepheromoneattractantsdependsuponmalesocialstatus