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Regulation of volatile and non-volatile pheromone attractants depends upon male social status
We investigated the regulation of chemical signals of house mice living in seminatural social conditions. We found that male mice more than doubled the excretion of major urinary proteins (MUPs) after they acquired a territory and become socially dominant. MUPs bind and stabilize the release of vola...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346026/ https://www.ncbi.nlm.nih.gov/pubmed/30679546 http://dx.doi.org/10.1038/s41598-018-36887-y |
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author | Thoß, M. Luzynski, K. C. Enk, V. M. Razzazi-Fazeli, E. Kwak, J. Ortner, I. Penn, D. J. |
author_facet | Thoß, M. Luzynski, K. C. Enk, V. M. Razzazi-Fazeli, E. Kwak, J. Ortner, I. Penn, D. J. |
author_sort | Thoß, M. |
collection | PubMed |
description | We investigated the regulation of chemical signals of house mice living in seminatural social conditions. We found that male mice more than doubled the excretion of major urinary proteins (MUPs) after they acquired a territory and become socially dominant. MUPs bind and stabilize the release of volatile pheromone ligands, and some MUPs exhibit pheromonal properties themselves. We conducted olfactory assays and found that female mice were more attracted to the scent of dominant than subordinate males when they were in estrus. Yet, when male status was controlled, females were not attracted to urine with high MUP concentration, despite being comparable to levels of dominant males. To determine which compounds influence female attraction, we conducted additional analyses and found that dominant males differentially upregulated the excretion of particular MUPs, including the pheromone MUP20 (darcin), and a volatile pheromone that influences female reproductive physiology and behavior. Our findings show that once male house mice become territorial and socially dominant, they upregulate the amount and types of excreted MUPs, which increases the intensities of volatiles and the attractiveness of their urinary scent to sexually receptive females. |
format | Online Article Text |
id | pubmed-6346026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63460262019-01-29 Regulation of volatile and non-volatile pheromone attractants depends upon male social status Thoß, M. Luzynski, K. C. Enk, V. M. Razzazi-Fazeli, E. Kwak, J. Ortner, I. Penn, D. J. Sci Rep Article We investigated the regulation of chemical signals of house mice living in seminatural social conditions. We found that male mice more than doubled the excretion of major urinary proteins (MUPs) after they acquired a territory and become socially dominant. MUPs bind and stabilize the release of volatile pheromone ligands, and some MUPs exhibit pheromonal properties themselves. We conducted olfactory assays and found that female mice were more attracted to the scent of dominant than subordinate males when they were in estrus. Yet, when male status was controlled, females were not attracted to urine with high MUP concentration, despite being comparable to levels of dominant males. To determine which compounds influence female attraction, we conducted additional analyses and found that dominant males differentially upregulated the excretion of particular MUPs, including the pheromone MUP20 (darcin), and a volatile pheromone that influences female reproductive physiology and behavior. Our findings show that once male house mice become territorial and socially dominant, they upregulate the amount and types of excreted MUPs, which increases the intensities of volatiles and the attractiveness of their urinary scent to sexually receptive females. Nature Publishing Group UK 2019-01-24 /pmc/articles/PMC6346026/ /pubmed/30679546 http://dx.doi.org/10.1038/s41598-018-36887-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Thoß, M. Luzynski, K. C. Enk, V. M. Razzazi-Fazeli, E. Kwak, J. Ortner, I. Penn, D. J. Regulation of volatile and non-volatile pheromone attractants depends upon male social status |
title | Regulation of volatile and non-volatile pheromone attractants depends upon male social status |
title_full | Regulation of volatile and non-volatile pheromone attractants depends upon male social status |
title_fullStr | Regulation of volatile and non-volatile pheromone attractants depends upon male social status |
title_full_unstemmed | Regulation of volatile and non-volatile pheromone attractants depends upon male social status |
title_short | Regulation of volatile and non-volatile pheromone attractants depends upon male social status |
title_sort | regulation of volatile and non-volatile pheromone attractants depends upon male social status |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346026/ https://www.ncbi.nlm.nih.gov/pubmed/30679546 http://dx.doi.org/10.1038/s41598-018-36887-y |
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