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Soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography
Soluble urokinase plasminogen activation receptor (suPAR) is risk factor for kidney disease and biomarker for cardiovascular outcomes but long term longitudinal analyses in a large European cohort have not been perfomed. To hus, we studied suPAR in participants of the Ludwigshafen Risk and Cardiovas...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346054/ https://www.ncbi.nlm.nih.gov/pubmed/30679668 http://dx.doi.org/10.1038/s41598-018-36960-6 |
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author | Sommerer, Claudia Zeier, Martin Morath, Christian Reiser, Jochen Scharnagl, Hubert Stojakovic, Tatjana Delgado, Graciela E. März, Winfried Kleber, Marcus E. |
author_facet | Sommerer, Claudia Zeier, Martin Morath, Christian Reiser, Jochen Scharnagl, Hubert Stojakovic, Tatjana Delgado, Graciela E. März, Winfried Kleber, Marcus E. |
author_sort | Sommerer, Claudia |
collection | PubMed |
description | Soluble urokinase plasminogen activation receptor (suPAR) is risk factor for kidney disease and biomarker for cardiovascular outcomes but long term longitudinal analyses in a large European cohort have not been perfomed. To hus, we studied suPAR in participants of the Ludwigshafen Risk and Cardiovascular Health study over a very long follow-up time of nearly 10 years. We estimated overall risk of all-cause and cardiovascular death by Cox proportional hazards regression according to quartiles of suPAR, including age, sex, use of lipid-lowering drugs, body mass index, diabetes mellitus, hypertension, smoking, lipids, as well as glomerular filtration rate (eGFR), NT-proBNP, interleukin-6 and high-sensitive CRP as covariates. A total of 2940 participants (age 62.7 ± 10.5years) having a median eGFR of 83.8 mL/min/1.73 m(2) were included. The median suPAR concentration was 3010 pg/mL (interquartile range, 2250–3988 pg/mL). Using the lowest quartile of suPAR as the reference, crude hazard ratio for cardiovascular mortality were 1.58 (95% CI 1.16–2.16), 1.85 (95% CI 1.37–2.52) and 2.75 (95% CI 2.03–3.71) in the second, third and fourth quartile, respectively. Adjusting for NT-proBNPeGFR or inflammation (interleukin-6 and high-sensitive CRP) confirmed results. suPAR predicts all-cause and cardiovascular death over a period of ten years in persons undergoing coronary angiography, independent of the natriuretic peptide NT-proBNP, kidney function and of markers of systemic inflammation. Future investigation into a potential causal role of suPAR in cardiovascular disease is warranted. |
format | Online Article Text |
id | pubmed-6346054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63460542019-01-29 Soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography Sommerer, Claudia Zeier, Martin Morath, Christian Reiser, Jochen Scharnagl, Hubert Stojakovic, Tatjana Delgado, Graciela E. März, Winfried Kleber, Marcus E. Sci Rep Article Soluble urokinase plasminogen activation receptor (suPAR) is risk factor for kidney disease and biomarker for cardiovascular outcomes but long term longitudinal analyses in a large European cohort have not been perfomed. To hus, we studied suPAR in participants of the Ludwigshafen Risk and Cardiovascular Health study over a very long follow-up time of nearly 10 years. We estimated overall risk of all-cause and cardiovascular death by Cox proportional hazards regression according to quartiles of suPAR, including age, sex, use of lipid-lowering drugs, body mass index, diabetes mellitus, hypertension, smoking, lipids, as well as glomerular filtration rate (eGFR), NT-proBNP, interleukin-6 and high-sensitive CRP as covariates. A total of 2940 participants (age 62.7 ± 10.5years) having a median eGFR of 83.8 mL/min/1.73 m(2) were included. The median suPAR concentration was 3010 pg/mL (interquartile range, 2250–3988 pg/mL). Using the lowest quartile of suPAR as the reference, crude hazard ratio for cardiovascular mortality were 1.58 (95% CI 1.16–2.16), 1.85 (95% CI 1.37–2.52) and 2.75 (95% CI 2.03–3.71) in the second, third and fourth quartile, respectively. Adjusting for NT-proBNPeGFR or inflammation (interleukin-6 and high-sensitive CRP) confirmed results. suPAR predicts all-cause and cardiovascular death over a period of ten years in persons undergoing coronary angiography, independent of the natriuretic peptide NT-proBNP, kidney function and of markers of systemic inflammation. Future investigation into a potential causal role of suPAR in cardiovascular disease is warranted. Nature Publishing Group UK 2019-01-24 /pmc/articles/PMC6346054/ /pubmed/30679668 http://dx.doi.org/10.1038/s41598-018-36960-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Sommerer, Claudia Zeier, Martin Morath, Christian Reiser, Jochen Scharnagl, Hubert Stojakovic, Tatjana Delgado, Graciela E. März, Winfried Kleber, Marcus E. Soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography |
title | Soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography |
title_full | Soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography |
title_fullStr | Soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography |
title_full_unstemmed | Soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography |
title_short | Soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography |
title_sort | soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346054/ https://www.ncbi.nlm.nih.gov/pubmed/30679668 http://dx.doi.org/10.1038/s41598-018-36960-6 |
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