DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

Ataxia Telangiectasia (A-T) is neurodegenerative syndrome caused by inherited mutations inactivating the ATM kinase, a master regulator of the DNA damage response (DDR). What makes neurons vulnerable to ATM loss remains unclear. In this study we assessed on human iPSC-derived neurons whether the abn...

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Detalles Bibliográficos
Autores principales: Corti, Alessandro, Sota, Raina, Dugo, Matteo, Calogero, Raffaele A., Terragni, Benedetta, Mantegazza, Massimo, Franceschetti, Silvana, Restelli, Michela, Gasparini, Patrizia, Lecis, Daniele, Chrzanowska, Krystyna H., Delia, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346060/
https://www.ncbi.nlm.nih.gov/pubmed/30679601
http://dx.doi.org/10.1038/s41598-018-36912-0

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