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Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner
The tetrameric G protein-gated K(+) channels (GIRKs) mediate inhibitory effects of neurotransmitters that activate G(i/o)-coupled receptors. GIRKs are activated by binding of the Gβγ dimer, via contacts with Gβ. Gγ underlies membrane targeting of Gβγ, but has not been implicated in channel gating. W...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346094/ https://www.ncbi.nlm.nih.gov/pubmed/30679535 http://dx.doi.org/10.1038/s41598-018-36833-y |