Cargando…

Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial

Infant formulae have been used since decades as an alternative to or a complement to human milk. Human milk, the “gold standard” of infant nutrition, has been studied for its properties in order to create infant formulae that bring similar benefits to the infant. One of the characteristics of milk i...

Descripción completa

Detalles Bibliográficos
Autores principales: Smolinska, A., Baranska, A., Dallinga, J. W., Mensink, R. P., Baumgartner, S., van de Heijning, B. J. M., van Schooten, F. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346115/
https://www.ncbi.nlm.nih.gov/pubmed/30679671
http://dx.doi.org/10.1038/s41598-018-37210-5
_version_ 1783389701034475520
author Smolinska, A.
Baranska, A.
Dallinga, J. W.
Mensink, R. P.
Baumgartner, S.
van de Heijning, B. J. M.
van Schooten, F. J.
author_facet Smolinska, A.
Baranska, A.
Dallinga, J. W.
Mensink, R. P.
Baumgartner, S.
van de Heijning, B. J. M.
van Schooten, F. J.
author_sort Smolinska, A.
collection PubMed
description Infant formulae have been used since decades as an alternative to or a complement to human milk. Human milk, the “gold standard” of infant nutrition, has been studied for its properties in order to create infant formulae that bring similar benefits to the infant. One of the characteristics of milk is the size of the lipid droplets which is known to affect the digestion, gastric emptying and triglyceride metabolism. In the current study a concept infant milk formula with large, phospholipid coating of lipid droplets (mode diameter 3–5 μm; NUTURIS, further described as “active”), was compared to a commercially available formula milk characterised by smaller lipid droplets, further described as “control” (both products derived from Nutricia). We investigated whether we could find an effect of lipid droplet size on volatile compounds in exhaled air upon ingestion of either product. For that purpose, exhaled breath was collected from a group of 29 healthy, non-smoking adult males before ingestion of a study product (baseline measurements, T0) and at the following time points after the test meal: 30, 60, 120, 180 and 240 min. Volatile organic compounds (VOCs) in breath were detected by gas chromatography-time-of-flight-mass spectrometry. Any differences in the time course of VOCs patterns upon intake of active and control products were investigated by regularised multivariate analysis of variance (rMANOVA). The rMANOVA analysis revealed statistically significant differences in the exhaled breath composition 240 min after ingestion of the active formula compared to control product (p-value < 0.0001), but did not show significant changes between active and control product at any earlier time points. A set of eight VOCs in exhaled breath had the highest contribution to the difference found at 240 minutes between the two formulas. A set of ten VOCs was different between baseline and the two formulae at T240 with p-value < 0.0001. To our knowledge this is the first study that shows the ability of VOCs in exhaled breath to monitor metabolic effects after ingestion of infant formulae with different lipid structure. The statistically significant differences in compound abundance found between active and control formula milk may be related to: (i) specific differences in the digestion, (ii) absorption of lipids and proteins and (iii) assimilation of the products in the gut.
format Online
Article
Text
id pubmed-6346115
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-63461152019-01-29 Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial Smolinska, A. Baranska, A. Dallinga, J. W. Mensink, R. P. Baumgartner, S. van de Heijning, B. J. M. van Schooten, F. J. Sci Rep Article Infant formulae have been used since decades as an alternative to or a complement to human milk. Human milk, the “gold standard” of infant nutrition, has been studied for its properties in order to create infant formulae that bring similar benefits to the infant. One of the characteristics of milk is the size of the lipid droplets which is known to affect the digestion, gastric emptying and triglyceride metabolism. In the current study a concept infant milk formula with large, phospholipid coating of lipid droplets (mode diameter 3–5 μm; NUTURIS, further described as “active”), was compared to a commercially available formula milk characterised by smaller lipid droplets, further described as “control” (both products derived from Nutricia). We investigated whether we could find an effect of lipid droplet size on volatile compounds in exhaled air upon ingestion of either product. For that purpose, exhaled breath was collected from a group of 29 healthy, non-smoking adult males before ingestion of a study product (baseline measurements, T0) and at the following time points after the test meal: 30, 60, 120, 180 and 240 min. Volatile organic compounds (VOCs) in breath were detected by gas chromatography-time-of-flight-mass spectrometry. Any differences in the time course of VOCs patterns upon intake of active and control products were investigated by regularised multivariate analysis of variance (rMANOVA). The rMANOVA analysis revealed statistically significant differences in the exhaled breath composition 240 min after ingestion of the active formula compared to control product (p-value < 0.0001), but did not show significant changes between active and control product at any earlier time points. A set of eight VOCs in exhaled breath had the highest contribution to the difference found at 240 minutes between the two formulas. A set of ten VOCs was different between baseline and the two formulae at T240 with p-value < 0.0001. To our knowledge this is the first study that shows the ability of VOCs in exhaled breath to monitor metabolic effects after ingestion of infant formulae with different lipid structure. The statistically significant differences in compound abundance found between active and control formula milk may be related to: (i) specific differences in the digestion, (ii) absorption of lipids and proteins and (iii) assimilation of the products in the gut. Nature Publishing Group UK 2019-01-24 /pmc/articles/PMC6346115/ /pubmed/30679671 http://dx.doi.org/10.1038/s41598-018-37210-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Smolinska, A.
Baranska, A.
Dallinga, J. W.
Mensink, R. P.
Baumgartner, S.
van de Heijning, B. J. M.
van Schooten, F. J.
Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial
title Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial
title_full Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial
title_fullStr Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial
title_full_unstemmed Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial
title_short Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial
title_sort comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346115/
https://www.ncbi.nlm.nih.gov/pubmed/30679671
http://dx.doi.org/10.1038/s41598-018-37210-5
work_keys_str_mv AT smolinskaa comparingpatternsofvolatileorganiccompoundsexhaledinbreathafterconsumptionoftwoinfantformulaewithadifferentlipidstructurearandomizedtrial
AT baranskaa comparingpatternsofvolatileorganiccompoundsexhaledinbreathafterconsumptionoftwoinfantformulaewithadifferentlipidstructurearandomizedtrial
AT dallingajw comparingpatternsofvolatileorganiccompoundsexhaledinbreathafterconsumptionoftwoinfantformulaewithadifferentlipidstructurearandomizedtrial
AT mensinkrp comparingpatternsofvolatileorganiccompoundsexhaledinbreathafterconsumptionoftwoinfantformulaewithadifferentlipidstructurearandomizedtrial
AT baumgartners comparingpatternsofvolatileorganiccompoundsexhaledinbreathafterconsumptionoftwoinfantformulaewithadifferentlipidstructurearandomizedtrial
AT vandeheijningbjm comparingpatternsofvolatileorganiccompoundsexhaledinbreathafterconsumptionoftwoinfantformulaewithadifferentlipidstructurearandomizedtrial
AT vanschootenfj comparingpatternsofvolatileorganiccompoundsexhaledinbreathafterconsumptionoftwoinfantformulaewithadifferentlipidstructurearandomizedtrial