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Cerebrospinal fluid from Alzheimer’s disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer’s disease

Mesenchymal stem cells (MSCs) have emerged as one of the promising treatment options for Alzheimer’s disease (AD). Although many studies have investigated on the efficacy of MSCs in AD, how MSCs actually change following exposure to the AD environment has not been studied extensively. In this study,...

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Autores principales: Lee, Jeongmin, Kwon, Soo Jin, Kim, Jang Hoon, Jang, Hyemin, Lee, Na Kyung, Hwang, Jung Won, Kim, Jong Hwa, Chang, Jong Wook, Na, Duk L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346116/
https://www.ncbi.nlm.nih.gov/pubmed/30679696
http://dx.doi.org/10.1038/s41598-018-37252-9
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author Lee, Jeongmin
Kwon, Soo Jin
Kim, Jang Hoon
Jang, Hyemin
Lee, Na Kyung
Hwang, Jung Won
Kim, Jong Hwa
Chang, Jong Wook
Na, Duk L.
author_facet Lee, Jeongmin
Kwon, Soo Jin
Kim, Jang Hoon
Jang, Hyemin
Lee, Na Kyung
Hwang, Jung Won
Kim, Jong Hwa
Chang, Jong Wook
Na, Duk L.
author_sort Lee, Jeongmin
collection PubMed
description Mesenchymal stem cells (MSCs) have emerged as one of the promising treatment options for Alzheimer’s disease (AD). Although many studies have investigated on the efficacy of MSCs in AD, how MSCs actually change following exposure to the AD environment has not been studied extensively. In this study, we investigated on the potential of AD patient-cerebrospinal fluid (CSF) samples to be used as a formulation of MSCs and its application in AD therapeutics. When Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) were stored in the CSF of AD patients, the stemness of WJ-MSCs was preserved. Furthermore, several genes were upregulated following storage in AD CSF. This signified the therapeutic potential of CSF formulation for AD therapy. Overall, these findings suggest that CSF from AD patients can be an optimal source for MSC formulation.
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spelling pubmed-63461162019-01-29 Cerebrospinal fluid from Alzheimer’s disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer’s disease Lee, Jeongmin Kwon, Soo Jin Kim, Jang Hoon Jang, Hyemin Lee, Na Kyung Hwang, Jung Won Kim, Jong Hwa Chang, Jong Wook Na, Duk L. Sci Rep Article Mesenchymal stem cells (MSCs) have emerged as one of the promising treatment options for Alzheimer’s disease (AD). Although many studies have investigated on the efficacy of MSCs in AD, how MSCs actually change following exposure to the AD environment has not been studied extensively. In this study, we investigated on the potential of AD patient-cerebrospinal fluid (CSF) samples to be used as a formulation of MSCs and its application in AD therapeutics. When Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) were stored in the CSF of AD patients, the stemness of WJ-MSCs was preserved. Furthermore, several genes were upregulated following storage in AD CSF. This signified the therapeutic potential of CSF formulation for AD therapy. Overall, these findings suggest that CSF from AD patients can be an optimal source for MSC formulation. Nature Publishing Group UK 2019-01-24 /pmc/articles/PMC6346116/ /pubmed/30679696 http://dx.doi.org/10.1038/s41598-018-37252-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lee, Jeongmin
Kwon, Soo Jin
Kim, Jang Hoon
Jang, Hyemin
Lee, Na Kyung
Hwang, Jung Won
Kim, Jong Hwa
Chang, Jong Wook
Na, Duk L.
Cerebrospinal fluid from Alzheimer’s disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer’s disease
title Cerebrospinal fluid from Alzheimer’s disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer’s disease
title_full Cerebrospinal fluid from Alzheimer’s disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer’s disease
title_fullStr Cerebrospinal fluid from Alzheimer’s disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer’s disease
title_full_unstemmed Cerebrospinal fluid from Alzheimer’s disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer’s disease
title_short Cerebrospinal fluid from Alzheimer’s disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer’s disease
title_sort cerebrospinal fluid from alzheimer’s disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346116/
https://www.ncbi.nlm.nih.gov/pubmed/30679696
http://dx.doi.org/10.1038/s41598-018-37252-9
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