A Series of Analogues to the AT(2)R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

We here report on our continued studies of ligands binding to the promising drug target angiotensin II type 2 receptor (AT(2)R). Two series of compounds were synthesized and investigated. The first series explored the effects of adding small substituents to the phenyl ring of the known selective non...

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Detalles Bibliográficos
Autores principales: Isaksson, Rebecka, Lindman, Jens, Wannberg, Johan, Sallander, Jessica, Backlund, Maria, Baraldi, Dhaniel, Widdop, Robert, Hallberg, Mathias, Åqvist, Johan, Gutierrez de Teran, Hugo, Gising, Johan, Larhed, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346239/
https://www.ncbi.nlm.nih.gov/pubmed/30697513
http://dx.doi.org/10.1002/open.201800282

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