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Second primary cancer after female breast cancer: Familial risks and cause of death

BACKGROUND: With continuous increases in survival rates following breast cancer (BC) diagnosis, the challenge of multiple primary cancers has become an issue. The data on familial risk of SPCs after BC diagnosis and the related mortality in BC patients are scarce. METHODS: A total of 87 752 female B...

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Autores principales: Zheng, Guoqiao, Hemminki, Akseli, Försti, Asta, Sundquist, Jan, Sundquist, Kristina, Hemminki, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346247/
https://www.ncbi.nlm.nih.gov/pubmed/30479046
http://dx.doi.org/10.1002/cam4.1899
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author Zheng, Guoqiao
Hemminki, Akseli
Försti, Asta
Sundquist, Jan
Sundquist, Kristina
Hemminki, Kari
author_facet Zheng, Guoqiao
Hemminki, Akseli
Försti, Asta
Sundquist, Jan
Sundquist, Kristina
Hemminki, Kari
author_sort Zheng, Guoqiao
collection PubMed
description BACKGROUND: With continuous increases in survival rates following breast cancer (BC) diagnosis, the challenge of multiple primary cancers has become an issue. The data on familial risk of SPCs after BC diagnosis and the related mortality in BC patients are scarce. METHODS: A total of 87 752 female BC patients were followed for SPC diagnoses and records of death. Relative risks (RRs) of SPC in BC patients who had first‐degree relatives (parents or siblings) affected by the same cancer were compared to the patients without family history. Causes of death were compared between patients with and without SPC. RESULTS: After a median follow‐up of 5 years, 14 952 BC patients developed SPCs, among which 10 280 (68.8%) had first‐degree relatives diagnosed with cancer. Familial risks were significant for 14 site‐specific SPCs, and the highest risk was for second ovarian cancer (RR = 6.28, 95%CI: 4.50‐8.75), compared to those without family history (1.49, 1.34‐1.65). In patients with SPC, SPC was the main cause of death, including diverse cancers and BC in approximately equal proportions. CONCLUSIONS: Family history contributed to the excess number of patients with SPCs, and SPC was the leading cause of death in patients with SPC. Taking family history at diagnosis of BC may provide warning signs with regard to possible subsequent SPCs and may offer possibilities for counseling, intervention and management.
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spelling pubmed-63462472019-01-29 Second primary cancer after female breast cancer: Familial risks and cause of death Zheng, Guoqiao Hemminki, Akseli Försti, Asta Sundquist, Jan Sundquist, Kristina Hemminki, Kari Cancer Med Cancer Prevention BACKGROUND: With continuous increases in survival rates following breast cancer (BC) diagnosis, the challenge of multiple primary cancers has become an issue. The data on familial risk of SPCs after BC diagnosis and the related mortality in BC patients are scarce. METHODS: A total of 87 752 female BC patients were followed for SPC diagnoses and records of death. Relative risks (RRs) of SPC in BC patients who had first‐degree relatives (parents or siblings) affected by the same cancer were compared to the patients without family history. Causes of death were compared between patients with and without SPC. RESULTS: After a median follow‐up of 5 years, 14 952 BC patients developed SPCs, among which 10 280 (68.8%) had first‐degree relatives diagnosed with cancer. Familial risks were significant for 14 site‐specific SPCs, and the highest risk was for second ovarian cancer (RR = 6.28, 95%CI: 4.50‐8.75), compared to those without family history (1.49, 1.34‐1.65). In patients with SPC, SPC was the main cause of death, including diverse cancers and BC in approximately equal proportions. CONCLUSIONS: Family history contributed to the excess number of patients with SPCs, and SPC was the leading cause of death in patients with SPC. Taking family history at diagnosis of BC may provide warning signs with regard to possible subsequent SPCs and may offer possibilities for counseling, intervention and management. John Wiley and Sons Inc. 2018-11-26 /pmc/articles/PMC6346247/ /pubmed/30479046 http://dx.doi.org/10.1002/cam4.1899 Text en © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Zheng, Guoqiao
Hemminki, Akseli
Försti, Asta
Sundquist, Jan
Sundquist, Kristina
Hemminki, Kari
Second primary cancer after female breast cancer: Familial risks and cause of death
title Second primary cancer after female breast cancer: Familial risks and cause of death
title_full Second primary cancer after female breast cancer: Familial risks and cause of death
title_fullStr Second primary cancer after female breast cancer: Familial risks and cause of death
title_full_unstemmed Second primary cancer after female breast cancer: Familial risks and cause of death
title_short Second primary cancer after female breast cancer: Familial risks and cause of death
title_sort second primary cancer after female breast cancer: familial risks and cause of death
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346247/
https://www.ncbi.nlm.nih.gov/pubmed/30479046
http://dx.doi.org/10.1002/cam4.1899
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