A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light

[Image: see text] Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multikilogram production. We have developed a...

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Autores principales: Harper, Kaid C., Moschetta, Eric G., Bordawekar, Shailendra V., Wittenberger, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346387/
https://www.ncbi.nlm.nih.gov/pubmed/30693330
http://dx.doi.org/10.1021/acscentsci.8b00728
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author Harper, Kaid C.
Moschetta, Eric G.
Bordawekar, Shailendra V.
Wittenberger, Steven J.
author_facet Harper, Kaid C.
Moschetta, Eric G.
Bordawekar, Shailendra V.
Wittenberger, Steven J.
author_sort Harper, Kaid C.
collection PubMed
description [Image: see text] Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multikilogram production. We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high-intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer–Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochemical reactions.
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spelling pubmed-63463872019-01-28 A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light Harper, Kaid C. Moschetta, Eric G. Bordawekar, Shailendra V. Wittenberger, Steven J. ACS Cent Sci [Image: see text] Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multikilogram production. We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high-intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer–Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochemical reactions. American Chemical Society 2019-01-07 2019-01-23 /pmc/articles/PMC6346387/ /pubmed/30693330 http://dx.doi.org/10.1021/acscentsci.8b00728 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Harper, Kaid C.
Moschetta, Eric G.
Bordawekar, Shailendra V.
Wittenberger, Steven J.
A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
title A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
title_full A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
title_fullStr A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
title_full_unstemmed A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
title_short A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
title_sort laser driven flow chemistry platform for scaling photochemical reactions with visible light
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346387/
https://www.ncbi.nlm.nih.gov/pubmed/30693330
http://dx.doi.org/10.1021/acscentsci.8b00728
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