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The Importance of Salt-Enhanced Electrostatic Repulsion in Colloidal Crystal Engineering with DNA
[Image: see text] Realizing functional colloidal single crystals requires precise control over nanoparticles in three dimensions across multiple size regimes. In this regard, colloidal crystallization with programmable atom equivalents (PAEs) composed of DNA-modified nanoparticles allows one to prog...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346395/ https://www.ncbi.nlm.nih.gov/pubmed/30693337 http://dx.doi.org/10.1021/acscentsci.8b00826 |
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author | Seo, Soyoung E. Girard, Martin de la Cruz, Monica Olvera Mirkin, Chad A. |
author_facet | Seo, Soyoung E. Girard, Martin de la Cruz, Monica Olvera Mirkin, Chad A. |
author_sort | Seo, Soyoung E. |
collection | PubMed |
description | [Image: see text] Realizing functional colloidal single crystals requires precise control over nanoparticles in three dimensions across multiple size regimes. In this regard, colloidal crystallization with programmable atom equivalents (PAEs) composed of DNA-modified nanoparticles allows one to program in a sequence-specific manner crystal symmetry, lattice parameter, and, in certain cases, crystal habit. Here, we explore how salt and the electrostatic properties of DNA regulate the attachment kinetics between PAEs. Counterintuitively, simulations and theory show that at high salt concentrations (1 M NaCl), the energy barrier for crystal growth increases by over an order of magnitude compared to low concentration (0.3 M), resulting in a transition from interface-limited to diffusion-limited crystal growth at larger crystal sizes. Remarkably, at elevated salt concentrations, well-formed rhombic dodecahedron-shaped microcrystals up to 21 μm in size grow, whereas at low salt concentration, the crystal size typically does not exceed 2 μm. Simulations show an increased barrier to hybridization between complementary PAEs at elevated salt concentrations. Therefore, although one might intuitively conclude that higher salt concentration would lead to less electrostatic repulsion and faster PAE-to-PAE hybridization kinetics, the opposite is the case, especially at larger inter-PAE distances. These observations provide important insight into how solution ionic strength can be used to control the attachment kinetics of nanoparticles coated with charged polymeric materials in general and DNA in particular. |
format | Online Article Text |
id | pubmed-6346395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-63463952019-01-28 The Importance of Salt-Enhanced Electrostatic Repulsion in Colloidal Crystal Engineering with DNA Seo, Soyoung E. Girard, Martin de la Cruz, Monica Olvera Mirkin, Chad A. ACS Cent Sci [Image: see text] Realizing functional colloidal single crystals requires precise control over nanoparticles in three dimensions across multiple size regimes. In this regard, colloidal crystallization with programmable atom equivalents (PAEs) composed of DNA-modified nanoparticles allows one to program in a sequence-specific manner crystal symmetry, lattice parameter, and, in certain cases, crystal habit. Here, we explore how salt and the electrostatic properties of DNA regulate the attachment kinetics between PAEs. Counterintuitively, simulations and theory show that at high salt concentrations (1 M NaCl), the energy barrier for crystal growth increases by over an order of magnitude compared to low concentration (0.3 M), resulting in a transition from interface-limited to diffusion-limited crystal growth at larger crystal sizes. Remarkably, at elevated salt concentrations, well-formed rhombic dodecahedron-shaped microcrystals up to 21 μm in size grow, whereas at low salt concentration, the crystal size typically does not exceed 2 μm. Simulations show an increased barrier to hybridization between complementary PAEs at elevated salt concentrations. Therefore, although one might intuitively conclude that higher salt concentration would lead to less electrostatic repulsion and faster PAE-to-PAE hybridization kinetics, the opposite is the case, especially at larger inter-PAE distances. These observations provide important insight into how solution ionic strength can be used to control the attachment kinetics of nanoparticles coated with charged polymeric materials in general and DNA in particular. American Chemical Society 2019-01-08 2019-01-23 /pmc/articles/PMC6346395/ /pubmed/30693337 http://dx.doi.org/10.1021/acscentsci.8b00826 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Seo, Soyoung E. Girard, Martin de la Cruz, Monica Olvera Mirkin, Chad A. The Importance of Salt-Enhanced Electrostatic Repulsion in Colloidal Crystal Engineering with DNA |
title | The Importance of Salt-Enhanced Electrostatic Repulsion
in Colloidal Crystal Engineering with DNA |
title_full | The Importance of Salt-Enhanced Electrostatic Repulsion
in Colloidal Crystal Engineering with DNA |
title_fullStr | The Importance of Salt-Enhanced Electrostatic Repulsion
in Colloidal Crystal Engineering with DNA |
title_full_unstemmed | The Importance of Salt-Enhanced Electrostatic Repulsion
in Colloidal Crystal Engineering with DNA |
title_short | The Importance of Salt-Enhanced Electrostatic Repulsion
in Colloidal Crystal Engineering with DNA |
title_sort | importance of salt-enhanced electrostatic repulsion
in colloidal crystal engineering with dna |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346395/ https://www.ncbi.nlm.nih.gov/pubmed/30693337 http://dx.doi.org/10.1021/acscentsci.8b00826 |
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