Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil

In seroconversion panels obtained from patients from Brazil, diagnostic testing for Zika virus infection was improved by combining multiple antibody isotypes, techniques, and antigens, but sensitivity remained suboptimal. In contrast, chikungunya virus diagnostic testing was unambiguous. Recurrent r...

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Detalles Bibliográficos
Autores principales: Bozza, Fernando A., Moreira-Soto, Andres, Rockstroh, Alexandra, Fischer, Carlo, Nascimento, Alessandra D., Calheiros, Andrea S., Drosten, Christian, Bozza, Patrícia T., Souza, Thiago Moreno L., Ulbert, Sebastian, Drexler, Jan Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346451/
https://www.ncbi.nlm.nih.gov/pubmed/30666934
http://dx.doi.org/10.3201/eid2502.180166
Descripción
Sumario:In seroconversion panels obtained from patients from Brazil, diagnostic testing for Zika virus infection was improved by combining multiple antibody isotypes, techniques, and antigens, but sensitivity remained suboptimal. In contrast, chikungunya virus diagnostic testing was unambiguous. Recurrent recent arbovirus infections suggested by serologic data and unspecific symptoms highlight the need for exhaustive virologic testing.

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