Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans

Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are ch...

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Detalles Bibliográficos
Autores principales: McElroy, Anita K., Shrivastava-Ranjan, Punya, Harmon, Jessica R., Martines, Roosecelis B., Silva-Flannery, Luciana, Flietstra, Timothy D., Kraft, Colleen S., Mehta, Aneesh K., Lyon, G. Marshall, Varkey, Jay B., Ribner, Bruce S., Nichol, Stuart T., Zaki, Sherif R., Spiropoulou, Christina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346465/
https://www.ncbi.nlm.nih.gov/pubmed/30666927
http://dx.doi.org/10.3201/eid2502.181326
Descripción
Sumario:Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. Furthermore, substantial immunoreactivity of host tissues to a CD163-specific antibody, predominantly in areas of extensive immunostaining for Ebola virus antigens, was observed in fatal cases. These data suggest that host macrophage activation contributes to EVD pathogenesis and that directed antiinflammatory therapies could be beneficial in the treatment of EVD.

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