Cargando…

Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report

INTRODUCTION: Simultaneous occurrence of transient global amnesia and Takotsubo syndrome has been only rarely reported. Here we report another patient with a transient global amnesia and concomitant Takotsubo syndrome. CASE PRESENTATION: Our patient is a 64-year-old white man with a previous history...

Descripción completa

Detalles Bibliográficos
Autores principales: Finsterer, Josef, Stollberger, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346500/
https://www.ncbi.nlm.nih.gov/pubmed/30678717
http://dx.doi.org/10.1186/s13256-018-1928-0
_version_ 1783389763816914944
author Finsterer, Josef
Stollberger, Claudia
author_facet Finsterer, Josef
Stollberger, Claudia
author_sort Finsterer, Josef
collection PubMed
description INTRODUCTION: Simultaneous occurrence of transient global amnesia and Takotsubo syndrome has been only rarely reported. Here we report another patient with a transient global amnesia and concomitant Takotsubo syndrome. CASE PRESENTATION: Our patient is a 64-year-old white man with a previous history of myocarditis from borreliosis who developed sudden-onset confusional state with perseverations and repetition of the same questions during a funeral for his brother-in-law. Upon neurological work-up and after spontaneous resolution of most of the neurological deficits, transient global amnesia was diagnosed. Blood tests revealed moderate renal insufficiency, elevated troponin-T, and elevated N-terminal prohormone of brain natriuretic peptide. Electrocardiography showed left anterior hemiblock and negative T-waves in V2–V6. Upon transthoracic echocardiography the apical type of a Takotsubo syndrome was suspected. Since coronary angiography was normal and electrocardiography and echocardiographic abnormalities resolved under candesartan, bisoprolol, acetyl-salicylic acid, and atorvastatin within a few days after onset, Takotsubo syndrome was diagnosed. CONCLUSIONS: Since Takotsubo syndrome may be associated with transient global amnesia a causal relation may exist. A possible trigger for both conditions could be severe emotional stress from the loss of a close relative. A possible common pathomechanism could be overstimulation of adrenergic receptors in the myocardium, the cerebrum, or the coronary or cerebral arteries. Whether pre-existing myocardial compromise promotes the development of Takotsubo syndrome requires further investigations.
format Online
Article
Text
id pubmed-6346500
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-63465002019-01-29 Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report Finsterer, Josef Stollberger, Claudia J Med Case Rep Case Report INTRODUCTION: Simultaneous occurrence of transient global amnesia and Takotsubo syndrome has been only rarely reported. Here we report another patient with a transient global amnesia and concomitant Takotsubo syndrome. CASE PRESENTATION: Our patient is a 64-year-old white man with a previous history of myocarditis from borreliosis who developed sudden-onset confusional state with perseverations and repetition of the same questions during a funeral for his brother-in-law. Upon neurological work-up and after spontaneous resolution of most of the neurological deficits, transient global amnesia was diagnosed. Blood tests revealed moderate renal insufficiency, elevated troponin-T, and elevated N-terminal prohormone of brain natriuretic peptide. Electrocardiography showed left anterior hemiblock and negative T-waves in V2–V6. Upon transthoracic echocardiography the apical type of a Takotsubo syndrome was suspected. Since coronary angiography was normal and electrocardiography and echocardiographic abnormalities resolved under candesartan, bisoprolol, acetyl-salicylic acid, and atorvastatin within a few days after onset, Takotsubo syndrome was diagnosed. CONCLUSIONS: Since Takotsubo syndrome may be associated with transient global amnesia a causal relation may exist. A possible trigger for both conditions could be severe emotional stress from the loss of a close relative. A possible common pathomechanism could be overstimulation of adrenergic receptors in the myocardium, the cerebrum, or the coronary or cerebral arteries. Whether pre-existing myocardial compromise promotes the development of Takotsubo syndrome requires further investigations. BioMed Central 2019-01-25 /pmc/articles/PMC6346500/ /pubmed/30678717 http://dx.doi.org/10.1186/s13256-018-1928-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Finsterer, Josef
Stollberger, Claudia
Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report
title Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report
title_full Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report
title_fullStr Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report
title_full_unstemmed Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report
title_short Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report
title_sort simultaneous transient global amnesia and takotsubo syndrome after death of a relative: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346500/
https://www.ncbi.nlm.nih.gov/pubmed/30678717
http://dx.doi.org/10.1186/s13256-018-1928-0
work_keys_str_mv AT finstererjosef simultaneoustransientglobalamnesiaandtakotsubosyndromeafterdeathofarelativeacasereport
AT stollbergerclaudia simultaneoustransientglobalamnesiaandtakotsubosyndromeafterdeathofarelativeacasereport