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Leptin-deficient mice have altered three-dimensional growth plate histomorphometry
BACKGROUND: Leptin is an adipokine that regulates energy homeostasis and is also needed for normal bone growth and maintenance. Mutation in the lep gene, which characterizes the ob/ob mouse model, results in the development of obesity and type 2 diabetes mellitus, as well as reduced limb bone length...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346570/ https://www.ncbi.nlm.nih.gov/pubmed/30697359 http://dx.doi.org/10.1186/s13098-019-0402-5 |