Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

BACKGROUND: Since malaria parasites highly depend on ribose 5-phosphate for DNA and RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate pathway (PPP) is considered an excellent anti-malarial drug target. In Plasmodium, a bifunctional enzyme named glucose 6-phosphate...

Descripción completa

Detalles Bibliográficos
Autores principales: Haeussler, Kristina, Berneburg, Isabell, Jortzik, Esther, Hahn, Julia, Rahbari, Mahsa, Schulz, Norma, Preuss, Janina, Zapol’skii, Viktor A., Bode, Lars, Pinkerton, Anthony B., Kaufmann, Dieter E., Rahlfs, Stefan, Becker, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346587/
https://www.ncbi.nlm.nih.gov/pubmed/30683097
http://dx.doi.org/10.1186/s12936-019-2651-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346587/
https://www.ncbi.nlm.nih.gov/pubmed/30683097
http://dx.doi.org/10.1186/s12936-019-2651-z

Ejemplares similares