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Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

BACKGROUND: Since malaria parasites highly depend on ribose 5-phosphate for DNA and RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate pathway (PPP) is considered an excellent anti-malarial drug target. In Plasmodium, a bifunctional enzyme named glucose 6-phosphate...

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Detalles Bibliográficos
Autores principales:	Haeussler, Kristina, Berneburg, Isabell, Jortzik, Esther, Hahn, Julia, Rahbari, Mahsa, Schulz, Norma, Preuss, Janina, Zapol’skii, Viktor A., Bode, Lars, Pinkerton, Anthony B., Kaufmann, Dieter E., Rahlfs, Stefan, Becker, Katja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346587/ https://www.ncbi.nlm.nih.gov/pubmed/30683097 http://dx.doi.org/10.1186/s12936-019-2651-z

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