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Brain iron deposition in primary insomnia—An in vivo susceptibility‐weighted imaging study
BACKGROUND: To study the brain iron deposition and its relationships with cognitive impairment and sleep quality in primary insomnia (PI). METHODS: Thirty‐five patients with PI and 35 volunteers underwent MRI scanning using high‐resolution susceptibility‐weighted imaging sequence. Bilateral anterior...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346654/ https://www.ncbi.nlm.nih.gov/pubmed/30548431 http://dx.doi.org/10.1002/brb3.1138 |
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author | Chen, Lin Wei, Xin Liu, Chen Li, Chuanming Zhou, Zhenhua |
author_facet | Chen, Lin Wei, Xin Liu, Chen Li, Chuanming Zhou, Zhenhua |
author_sort | Chen, Lin |
collection | PubMed |
description | BACKGROUND: To study the brain iron deposition and its relationships with cognitive impairment and sleep quality in primary insomnia (PI). METHODS: Thirty‐five patients with PI and 35 volunteers underwent MRI scanning using high‐resolution susceptibility‐weighted imaging sequence. Bilateral anterior cingulate cortices, posterior cingulate cortex, hippocampus, caudate nucleus, globus pallidus, putamen, thalamus, red nucleus, substantia nigra, parietal cortex, and frontal white matter were selected as regions of interest. The phase shift values of the above areas were compared between the two groups. Partial correlations between phase shifts values and neuropsychological scale scores including Pittsburgh Sleep Quality Index, Insomnia Severity Index, Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living Scale, and Clinical Dementia Rating of the PI patients were analyzed. RESULTS: Compared with the normal controls, the PI patients showed significant lower MMSE and MoCA scores and increased phase shift values in the left caudate nucleus, left putamen, left hippocampus, and bilateral thalamus (p < 0.05). Close correlation was found between the phase shift value of the left hippocampus and the MMSE scores of the PI patients (R = −0.447, p < 0.01). CONCLUSION: The PI patients exhibited significant cognitive impairment and increased iron deposition in several brain regions. The iron concentration of the left hippocampus is a biomarker of cognitive impairment and may play an important role in the pathophysiological mechanism. |
format | Online Article Text |
id | pubmed-6346654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63466542019-01-29 Brain iron deposition in primary insomnia—An in vivo susceptibility‐weighted imaging study Chen, Lin Wei, Xin Liu, Chen Li, Chuanming Zhou, Zhenhua Brain Behav Original Research BACKGROUND: To study the brain iron deposition and its relationships with cognitive impairment and sleep quality in primary insomnia (PI). METHODS: Thirty‐five patients with PI and 35 volunteers underwent MRI scanning using high‐resolution susceptibility‐weighted imaging sequence. Bilateral anterior cingulate cortices, posterior cingulate cortex, hippocampus, caudate nucleus, globus pallidus, putamen, thalamus, red nucleus, substantia nigra, parietal cortex, and frontal white matter were selected as regions of interest. The phase shift values of the above areas were compared between the two groups. Partial correlations between phase shifts values and neuropsychological scale scores including Pittsburgh Sleep Quality Index, Insomnia Severity Index, Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living Scale, and Clinical Dementia Rating of the PI patients were analyzed. RESULTS: Compared with the normal controls, the PI patients showed significant lower MMSE and MoCA scores and increased phase shift values in the left caudate nucleus, left putamen, left hippocampus, and bilateral thalamus (p < 0.05). Close correlation was found between the phase shift value of the left hippocampus and the MMSE scores of the PI patients (R = −0.447, p < 0.01). CONCLUSION: The PI patients exhibited significant cognitive impairment and increased iron deposition in several brain regions. The iron concentration of the left hippocampus is a biomarker of cognitive impairment and may play an important role in the pathophysiological mechanism. John Wiley and Sons Inc. 2018-12-11 /pmc/articles/PMC6346654/ /pubmed/30548431 http://dx.doi.org/10.1002/brb3.1138 Text en © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Chen, Lin Wei, Xin Liu, Chen Li, Chuanming Zhou, Zhenhua Brain iron deposition in primary insomnia—An in vivo susceptibility‐weighted imaging study |
title | Brain iron deposition in primary insomnia—An in vivo susceptibility‐weighted imaging study |
title_full | Brain iron deposition in primary insomnia—An in vivo susceptibility‐weighted imaging study |
title_fullStr | Brain iron deposition in primary insomnia—An in vivo susceptibility‐weighted imaging study |
title_full_unstemmed | Brain iron deposition in primary insomnia—An in vivo susceptibility‐weighted imaging study |
title_short | Brain iron deposition in primary insomnia—An in vivo susceptibility‐weighted imaging study |
title_sort | brain iron deposition in primary insomnia—an in vivo susceptibility‐weighted imaging study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346654/ https://www.ncbi.nlm.nih.gov/pubmed/30548431 http://dx.doi.org/10.1002/brb3.1138 |
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