Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O(2) Sensitive Voltage-Gated K(+) Channels

Background: The purpose of this study is to elucidate mechanism(s) by which the orally active PGI2 analog, Beraprost (BPS), ameliorates pulmonary hypertension (PH). Prostaglandins are an important treatment for PH. Mechanisms of their action are not fully elucidated in relation to receptor subtype a...

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Detalles Bibliográficos
Autores principales: Fan, Fenling, Tian, Hua, Geng, Jie, Deng, Jizhao, Liu, Ya, Chen, Chunyan, Zhang, Songlin, Zhang, Yushun, Li, Jie, Tian, Hongyan, Dart, Anthony M., Zou, Yuliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346678/
https://www.ncbi.nlm.nih.gov/pubmed/30713496
http://dx.doi.org/10.3389/fphar.2018.01518

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