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Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient

INTRODUCTION: Kaposi’s sarcoma (KS) is an angioproliferative disorder first described in 1872 by Moritz Kaposi. Four main clinical presentations of KS have been described: classic, endemic, iatrogenic and epidemic. KS involvement of the lymph nodes is extremely uncommon in the classical variant form...

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Autores principales: Zoubeidi, Hana, Aydi, Zohra, Daoud, Fatma, Rachdi, Imen, Koubaa, Wafa, Jouini, Raja, Baili, Lilia, Debbiche, Achraf, Ben Dhaou, Besma, Boussema, Fatma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346768/
https://www.ncbi.nlm.nih.gov/pubmed/30755897
http://dx.doi.org/10.12890/2016_000493
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author Zoubeidi, Hana
Aydi, Zohra
Daoud, Fatma
Rachdi, Imen
Koubaa, Wafa
Jouini, Raja
Baili, Lilia
Debbiche, Achraf
Ben Dhaou, Besma
Boussema, Fatma
author_facet Zoubeidi, Hana
Aydi, Zohra
Daoud, Fatma
Rachdi, Imen
Koubaa, Wafa
Jouini, Raja
Baili, Lilia
Debbiche, Achraf
Ben Dhaou, Besma
Boussema, Fatma
author_sort Zoubeidi, Hana
collection PubMed
description INTRODUCTION: Kaposi’s sarcoma (KS) is an angioproliferative disorder first described in 1872 by Moritz Kaposi. Four main clinical presentations of KS have been described: classic, endemic, iatrogenic and epidemic. KS involvement of the lymph nodes is extremely uncommon in the classical variant form, especially if it precedes the skin manifestations. We describe the case of an elderly HIV-negative patient presenting with lymphadenopathy who was found to have KS. CASE REPORT: A 67-year-old patient was admitted for exploration of polyadenopathies in the context of a general decline in health. Physical examination revealed an erythematosus left lower limb rash associated with angiomatous nodules and multiple lymphadenopathies. The diagnosis of erysipelas in the left leg was retained and the patient was treated with good evolution of the rash but persistence of the angiomatous nodules and the polyadenopathies. Skin and lymph node biopsies led to a diagnosis of KS. The patient is proposed for polychemotherapy. CONCLUSION: KS must be suspected in lymphadenopathies despite the absence of typical cutaneous signs of the disease and in immunocompetent patients. LEARNING POINTS: Involvement of the lymph nodes is extremely uncommon in the classical variant form of Kaposi’s sarcoma (KS). Human herpes virus-8 is an important cofactor in all forms of KS. Pathology and immunohistochemistry are key to diagnosing KS. KS must be suspected in lymphadenopathies without typical cutaneous signs of the disease and in immunocompetent patients.
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spelling pubmed-63467682019-02-12 Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient Zoubeidi, Hana Aydi, Zohra Daoud, Fatma Rachdi, Imen Koubaa, Wafa Jouini, Raja Baili, Lilia Debbiche, Achraf Ben Dhaou, Besma Boussema, Fatma Eur J Case Rep Intern Med Articles INTRODUCTION: Kaposi’s sarcoma (KS) is an angioproliferative disorder first described in 1872 by Moritz Kaposi. Four main clinical presentations of KS have been described: classic, endemic, iatrogenic and epidemic. KS involvement of the lymph nodes is extremely uncommon in the classical variant form, especially if it precedes the skin manifestations. We describe the case of an elderly HIV-negative patient presenting with lymphadenopathy who was found to have KS. CASE REPORT: A 67-year-old patient was admitted for exploration of polyadenopathies in the context of a general decline in health. Physical examination revealed an erythematosus left lower limb rash associated with angiomatous nodules and multiple lymphadenopathies. The diagnosis of erysipelas in the left leg was retained and the patient was treated with good evolution of the rash but persistence of the angiomatous nodules and the polyadenopathies. Skin and lymph node biopsies led to a diagnosis of KS. The patient is proposed for polychemotherapy. CONCLUSION: KS must be suspected in lymphadenopathies despite the absence of typical cutaneous signs of the disease and in immunocompetent patients. LEARNING POINTS: Involvement of the lymph nodes is extremely uncommon in the classical variant form of Kaposi’s sarcoma (KS). Human herpes virus-8 is an important cofactor in all forms of KS. Pathology and immunohistochemistry are key to diagnosing KS. KS must be suspected in lymphadenopathies without typical cutaneous signs of the disease and in immunocompetent patients. SMC Media Srl 2016-09-19 /pmc/articles/PMC6346768/ /pubmed/30755897 http://dx.doi.org/10.12890/2016_000493 Text en © EFIM 2016 This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Articles
Zoubeidi, Hana
Aydi, Zohra
Daoud, Fatma
Rachdi, Imen
Koubaa, Wafa
Jouini, Raja
Baili, Lilia
Debbiche, Achraf
Ben Dhaou, Besma
Boussema, Fatma
Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient
title Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient
title_full Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient
title_fullStr Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient
title_full_unstemmed Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient
title_short Kaposi’s Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient
title_sort kaposi’s sarcoma presenting as lymphadenopathy in an immunocompetent patient
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346768/
https://www.ncbi.nlm.nih.gov/pubmed/30755897
http://dx.doi.org/10.12890/2016_000493
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