Fundic Gland Polyposis Associated with Proton-Pump Inhibitor Use

We describe the case of a man with fundic gland polyposis associated with proton-pump inhibitor (PPI) use. Some investigators have reported an association between long-term PPI use and an increase in the risk of developing fundic gland polyps (FGPs). These FGPs are considered to be reversible on stopping PPI treatment. The current patient had used a PPI for 10 years, resulting in multiple FGPs in his gastric body. However, 6 months after cessation of the PPI, the FGPs had obvously regressed, even though a histamine-2 receptor antagonist had subsequently been prescribed. This case demonstrates a link between PPI treatment and FGPs. LEARNING POINTS: Long-term proton-pump inhibitor (PPI) use can increase the risk of developing fundic gland polyps (FGPs). This phenomenon is thought to be reversible, and a few case reports have demonstrated spontaneous resolution of FGPs after cessation of PPI use. When fundic gland polyposis is detected, a family history of polyposis and a history of PPI use should both be sought.