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Computed Tomography Perfusion Can Guide Endovascular Therapy in Bilateral Carotid Artery Dissection

INTRODUCTION: Carotid artery dissection (CAD) is a major cause of stroke in those under age 45, accounting for around 20% of ischaemic events([1,2]). In the absence of known connective tissue disorders, most dissections are traumatic([2]). First-line management is comprised of antiplatelet or antico...

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Autores principales: Induruwa, Isuru, Bentham, Chloe, Khadjooi, Kayvan, Sharma, Nikhil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346824/
https://www.ncbi.nlm.nih.gov/pubmed/30755851
http://dx.doi.org/10.12890/2015_000295
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author Induruwa, Isuru
Bentham, Chloe
Khadjooi, Kayvan
Sharma, Nikhil
author_facet Induruwa, Isuru
Bentham, Chloe
Khadjooi, Kayvan
Sharma, Nikhil
author_sort Induruwa, Isuru
collection PubMed
description INTRODUCTION: Carotid artery dissection (CAD) is a major cause of stroke in those under age 45, accounting for around 20% of ischaemic events([1,2]). In the absence of known connective tissue disorders, most dissections are traumatic([2]). First-line management is comprised of antiplatelet or anticoagulation therapy, but many traumatic dissections progress despite this and carry the risk of long-term complications from embolism or stenosis([3]). We report a case of traumatic bilateral carotid dissection leading to progressive neurological symptoms and hypoperfusion on computed tomography perfusion (CTP), despite escalation in anticoagulation, which led to emergency carotid stenting. LEARNING POINTS: Carotid artery dissection should always be considered in young patients presenting with stroke. Most strokes are caused by emboli from the injured vessel but hypoperfusion, especially from bilateral dissections, can also cause stroke. Anticoagulation or antiplatelets are used as first-line therapy, though there are no randomised control trials to guide management. Failure of medical therapy can be common and endovascular therapy should be considered in these cases. Computed tomography perfusion (CTP) scanning can be useful because it highlights areas of ischaemic penumbra that may be salvageable through such intervention.
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spelling pubmed-63468242019-02-12 Computed Tomography Perfusion Can Guide Endovascular Therapy in Bilateral Carotid Artery Dissection Induruwa, Isuru Bentham, Chloe Khadjooi, Kayvan Sharma, Nikhil Eur J Case Rep Intern Med Articles INTRODUCTION: Carotid artery dissection (CAD) is a major cause of stroke in those under age 45, accounting for around 20% of ischaemic events([1,2]). In the absence of known connective tissue disorders, most dissections are traumatic([2]). First-line management is comprised of antiplatelet or anticoagulation therapy, but many traumatic dissections progress despite this and carry the risk of long-term complications from embolism or stenosis([3]). We report a case of traumatic bilateral carotid dissection leading to progressive neurological symptoms and hypoperfusion on computed tomography perfusion (CTP), despite escalation in anticoagulation, which led to emergency carotid stenting. LEARNING POINTS: Carotid artery dissection should always be considered in young patients presenting with stroke. Most strokes are caused by emboli from the injured vessel but hypoperfusion, especially from bilateral dissections, can also cause stroke. Anticoagulation or antiplatelets are used as first-line therapy, though there are no randomised control trials to guide management. Failure of medical therapy can be common and endovascular therapy should be considered in these cases. Computed tomography perfusion (CTP) scanning can be useful because it highlights areas of ischaemic penumbra that may be salvageable through such intervention. SMC Media Srl 2015-12-15 /pmc/articles/PMC6346824/ /pubmed/30755851 http://dx.doi.org/10.12890/2015_000295 Text en © EFIM 2015 This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Articles
Induruwa, Isuru
Bentham, Chloe
Khadjooi, Kayvan
Sharma, Nikhil
Computed Tomography Perfusion Can Guide Endovascular Therapy in Bilateral Carotid Artery Dissection
title Computed Tomography Perfusion Can Guide Endovascular Therapy in Bilateral Carotid Artery Dissection
title_full Computed Tomography Perfusion Can Guide Endovascular Therapy in Bilateral Carotid Artery Dissection
title_fullStr Computed Tomography Perfusion Can Guide Endovascular Therapy in Bilateral Carotid Artery Dissection
title_full_unstemmed Computed Tomography Perfusion Can Guide Endovascular Therapy in Bilateral Carotid Artery Dissection
title_short Computed Tomography Perfusion Can Guide Endovascular Therapy in Bilateral Carotid Artery Dissection
title_sort computed tomography perfusion can guide endovascular therapy in bilateral carotid artery dissection
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346824/
https://www.ncbi.nlm.nih.gov/pubmed/30755851
http://dx.doi.org/10.12890/2015_000295
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