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Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman

Non-compaction of the ventricular myocardium (NCM) is a genetic cardiomyopathy usually due to mutationof the G4.5 gene located in the Xq28 chromosomal region. This congenital disorder is characterized by pronounced trabeculations and intertrabecular recesses resulting from abnormal embryogenesis bet...

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Autores principales: Kochmareva, Elena A., Kokorin, Valentin A., Kondrashova, Evgenia A., Khokhlova, Nadejda V., Vardanyan, Argishti G., Kokorin, Ilya A., Doroshenko, Dmitry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346967/
https://www.ncbi.nlm.nih.gov/pubmed/30755883
http://dx.doi.org/10.12890/2016_000432
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author Kochmareva, Elena A.
Kokorin, Valentin A.
Kondrashova, Evgenia A.
Khokhlova, Nadejda V.
Vardanyan, Argishti G.
Kokorin, Ilya A.
Doroshenko, Dmitry A.
author_facet Kochmareva, Elena A.
Kokorin, Valentin A.
Kondrashova, Evgenia A.
Khokhlova, Nadejda V.
Vardanyan, Argishti G.
Kokorin, Ilya A.
Doroshenko, Dmitry A.
author_sort Kochmareva, Elena A.
collection PubMed
description Non-compaction of the ventricular myocardium (NCM) is a genetic cardiomyopathy usually due to mutationof the G4.5 gene located in the Xq28 chromosomal region. This congenital disorder is characterized by pronounced trabeculations and intertrabecular recesses resulting from abnormal embryogenesis between the fifth and eighth fetal weeks. The reported prevalence in the general population is between 0.014% and 1.3%. The classic triad of complications includes heart failure, ventricular arrhythmias and systemic embolic events, although some patients have an asymptomatic form. NCM is commonly diagnosed by echocardiography, but contrast ventriculography, CT and MRI can also be used. Here we present a case of left ventricle NCM, manifested after respiratory infection, in a pregnant patient with congenital thrombophilia and a history of myocardial infarction. LEARNING POINTS: Non-compaction myocardium (NCM) in pregnant women has been associated with a poor prognosis. We should avoid routinely recommending young women with NCM to refuse pregnancy. A decision to continue pregnancy should be made by the patient in discussion with specialists.
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spelling pubmed-63469672019-02-12 Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman Kochmareva, Elena A. Kokorin, Valentin A. Kondrashova, Evgenia A. Khokhlova, Nadejda V. Vardanyan, Argishti G. Kokorin, Ilya A. Doroshenko, Dmitry A. Eur J Case Rep Intern Med Articles Non-compaction of the ventricular myocardium (NCM) is a genetic cardiomyopathy usually due to mutationof the G4.5 gene located in the Xq28 chromosomal region. This congenital disorder is characterized by pronounced trabeculations and intertrabecular recesses resulting from abnormal embryogenesis between the fifth and eighth fetal weeks. The reported prevalence in the general population is between 0.014% and 1.3%. The classic triad of complications includes heart failure, ventricular arrhythmias and systemic embolic events, although some patients have an asymptomatic form. NCM is commonly diagnosed by echocardiography, but contrast ventriculography, CT and MRI can also be used. Here we present a case of left ventricle NCM, manifested after respiratory infection, in a pregnant patient with congenital thrombophilia and a history of myocardial infarction. LEARNING POINTS: Non-compaction myocardium (NCM) in pregnant women has been associated with a poor prognosis. We should avoid routinely recommending young women with NCM to refuse pregnancy. A decision to continue pregnancy should be made by the patient in discussion with specialists. SMC Media Srl 2016-06-22 /pmc/articles/PMC6346967/ /pubmed/30755883 http://dx.doi.org/10.12890/2016_000432 Text en © EFIM 2016 This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Articles
Kochmareva, Elena A.
Kokorin, Valentin A.
Kondrashova, Evgenia A.
Khokhlova, Nadejda V.
Vardanyan, Argishti G.
Kokorin, Ilya A.
Doroshenko, Dmitry A.
Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman
title Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman
title_full Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman
title_fullStr Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman
title_full_unstemmed Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman
title_short Left Ventricle Non-Compaction Myocardium and Thrombophilia in a Pregnant Woman
title_sort left ventricle non-compaction myocardium and thrombophilia in a pregnant woman
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346967/
https://www.ncbi.nlm.nih.gov/pubmed/30755883
http://dx.doi.org/10.12890/2016_000432
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