Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia

High-dose methotrexate (MTX) given in four hospitalizations during interim maintenance for high-risk pediatric B-lineage acute lymphocytic leukemia significantly improves survival but increases resource utilization. Children remain hospitalized for intravenous hydration and blood or urine monitoring...

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Autores principales: Bartholomew, Joy L., Dai, Hongying, August, Keith J., Ryan, Robin E., Stegenga, Kristin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Harborside Press 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347087/
https://www.ncbi.nlm.nih.gov/pubmed/30719391
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author Bartholomew, Joy L.
Dai, Hongying
August, Keith J.
Ryan, Robin E.
Stegenga, Kristin A.
author_facet Bartholomew, Joy L.
Dai, Hongying
August, Keith J.
Ryan, Robin E.
Stegenga, Kristin A.
author_sort Bartholomew, Joy L.
collection PubMed
description High-dose methotrexate (MTX) given in four hospitalizations during interim maintenance for high-risk pediatric B-lineage acute lymphocytic leukemia significantly improves survival but increases resource utilization. Children remain hospitalized for intravenous hydration and blood or urine monitoring until MTX clearance parameters are reached. Improved supportive care, extended infusion center hours, and pediatric home health expertise afford alternatives to prolonged hospital admissions, potentially offering quality, cost-effective approaches that positively impact the delivery of care.
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spelling pubmed-63470872019-02-04 Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia Bartholomew, Joy L. Dai, Hongying August, Keith J. Ryan, Robin E. Stegenga, Kristin A. J Adv Pract Oncol Review Article High-dose methotrexate (MTX) given in four hospitalizations during interim maintenance for high-risk pediatric B-lineage acute lymphocytic leukemia significantly improves survival but increases resource utilization. Children remain hospitalized for intravenous hydration and blood or urine monitoring until MTX clearance parameters are reached. Improved supportive care, extended infusion center hours, and pediatric home health expertise afford alternatives to prolonged hospital admissions, potentially offering quality, cost-effective approaches that positively impact the delivery of care. Harborside Press 2018 2018-05-01 /pmc/articles/PMC6347087/ /pubmed/30719391 Text en Copyright © 2018, Harborside Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited and is for non-commercial purposes.
spellingShingle Review Article
Bartholomew, Joy L.
Dai, Hongying
August, Keith J.
Ryan, Robin E.
Stegenga, Kristin A.
Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia
title Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia
title_full Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia
title_fullStr Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia
title_full_unstemmed Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia
title_short Feasibility of Outpatient High-Dose Methotrexate Infusions in Pediatric Patients With B-Lineage Acute Lymphoblastic Leukemia
title_sort feasibility of outpatient high-dose methotrexate infusions in pediatric patients with b-lineage acute lymphoblastic leukemia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347087/
https://www.ncbi.nlm.nih.gov/pubmed/30719391
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