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Lifelong aerobic exercise protects against inflammaging and cancer

Biological aging is associated with progressive damage accumulation, loss of organ reserves, and systemic inflammation ('inflammaging'), which predispose for a wide spectrum of chronic diseases, including several types of cancer. In contrast, aerobic exercise training (AET) reduces inflamm...

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Autores principales: Nilsson, Mats I., Bourgeois, Jacqueline M., Nederveen, Joshua P., Leite, Marlon R., Hettinga, Bart P., Bujak, Adam L., May, Linda, Lin, Ethan, Crozier, Michael, Rusiecki, Daniel R., Moffatt, Chris, Azzopardi, Paul, Young, Jacob, Yang, Yifan, Nguyen, Jenny, Adler, Ethan, Lan, Lucy, Tarnopolsky, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347267/
https://www.ncbi.nlm.nih.gov/pubmed/30682077
http://dx.doi.org/10.1371/journal.pone.0210863
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author Nilsson, Mats I.
Bourgeois, Jacqueline M.
Nederveen, Joshua P.
Leite, Marlon R.
Hettinga, Bart P.
Bujak, Adam L.
May, Linda
Lin, Ethan
Crozier, Michael
Rusiecki, Daniel R.
Moffatt, Chris
Azzopardi, Paul
Young, Jacob
Yang, Yifan
Nguyen, Jenny
Adler, Ethan
Lan, Lucy
Tarnopolsky, Mark A.
author_facet Nilsson, Mats I.
Bourgeois, Jacqueline M.
Nederveen, Joshua P.
Leite, Marlon R.
Hettinga, Bart P.
Bujak, Adam L.
May, Linda
Lin, Ethan
Crozier, Michael
Rusiecki, Daniel R.
Moffatt, Chris
Azzopardi, Paul
Young, Jacob
Yang, Yifan
Nguyen, Jenny
Adler, Ethan
Lan, Lucy
Tarnopolsky, Mark A.
author_sort Nilsson, Mats I.
collection PubMed
description Biological aging is associated with progressive damage accumulation, loss of organ reserves, and systemic inflammation ('inflammaging'), which predispose for a wide spectrum of chronic diseases, including several types of cancer. In contrast, aerobic exercise training (AET) reduces inflammation, lowers all-cause mortality, and enhances both health and lifespan. In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model (C57BL/J6). Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the ‘physiologic reserve’ of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokines and chemokines (P < 0.05 O-SED vs. 2-month-old Y-CON), was potently mitigated by lifelong AET (P < 0.05 O-AET vs. O-SED), including master regulators of the cytokine cascade and cancer progression (IL-1β, TNF-α, and IL-6). In addition, circulating SPARC, previously known to be upregulated in metabolic disease, was elevated in old, sedentary mice, but was normalized to young control levels in lifelong runners. Remarkably, malignant tumours were also completely absent in the O-AET group, whereas they were present in the brain (pituitary), liver, spleen, and intestines of sedentary mice. Collectively, our results indicate that early-onset, lifelong running dampens inflammaging, protects against multiple cancer types, and extends healthspan of naturally-aged mice.
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spelling pubmed-63472672019-02-02 Lifelong aerobic exercise protects against inflammaging and cancer Nilsson, Mats I. Bourgeois, Jacqueline M. Nederveen, Joshua P. Leite, Marlon R. Hettinga, Bart P. Bujak, Adam L. May, Linda Lin, Ethan Crozier, Michael Rusiecki, Daniel R. Moffatt, Chris Azzopardi, Paul Young, Jacob Yang, Yifan Nguyen, Jenny Adler, Ethan Lan, Lucy Tarnopolsky, Mark A. PLoS One Research Article Biological aging is associated with progressive damage accumulation, loss of organ reserves, and systemic inflammation ('inflammaging'), which predispose for a wide spectrum of chronic diseases, including several types of cancer. In contrast, aerobic exercise training (AET) reduces inflammation, lowers all-cause mortality, and enhances both health and lifespan. In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model (C57BL/J6). Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the ‘physiologic reserve’ of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokines and chemokines (P < 0.05 O-SED vs. 2-month-old Y-CON), was potently mitigated by lifelong AET (P < 0.05 O-AET vs. O-SED), including master regulators of the cytokine cascade and cancer progression (IL-1β, TNF-α, and IL-6). In addition, circulating SPARC, previously known to be upregulated in metabolic disease, was elevated in old, sedentary mice, but was normalized to young control levels in lifelong runners. Remarkably, malignant tumours were also completely absent in the O-AET group, whereas they were present in the brain (pituitary), liver, spleen, and intestines of sedentary mice. Collectively, our results indicate that early-onset, lifelong running dampens inflammaging, protects against multiple cancer types, and extends healthspan of naturally-aged mice. Public Library of Science 2019-01-25 /pmc/articles/PMC6347267/ /pubmed/30682077 http://dx.doi.org/10.1371/journal.pone.0210863 Text en © 2019 Nilsson et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nilsson, Mats I.
Bourgeois, Jacqueline M.
Nederveen, Joshua P.
Leite, Marlon R.
Hettinga, Bart P.
Bujak, Adam L.
May, Linda
Lin, Ethan
Crozier, Michael
Rusiecki, Daniel R.
Moffatt, Chris
Azzopardi, Paul
Young, Jacob
Yang, Yifan
Nguyen, Jenny
Adler, Ethan
Lan, Lucy
Tarnopolsky, Mark A.
Lifelong aerobic exercise protects against inflammaging and cancer
title Lifelong aerobic exercise protects against inflammaging and cancer
title_full Lifelong aerobic exercise protects against inflammaging and cancer
title_fullStr Lifelong aerobic exercise protects against inflammaging and cancer
title_full_unstemmed Lifelong aerobic exercise protects against inflammaging and cancer
title_short Lifelong aerobic exercise protects against inflammaging and cancer
title_sort lifelong aerobic exercise protects against inflammaging and cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347267/
https://www.ncbi.nlm.nih.gov/pubmed/30682077
http://dx.doi.org/10.1371/journal.pone.0210863
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