Synthetic lethality guiding selection of drug combinations in ovarian cancer

BACKGROUND: Synthetic lethality describes a relationship between two genes where single loss of either gene does not trigger significant impact on cell viability, but simultaneous loss of both gene functions results in lethality. Targeting synthetic lethal interactions with drug combinations promise...

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Detalles Bibliográficos
Autores principales: Heinzel, Andreas, Marhold, Maximilian, Mayer, Paul, Schwarz, Michael, Tomasich, Erwin, Lukas, Arno, Krainer, Michael, Perco, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347359/
https://www.ncbi.nlm.nih.gov/pubmed/30682083
http://dx.doi.org/10.1371/journal.pone.0210859

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