Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction

Phenytoin toxicity occurs when serum levels exceed the therapeutic level, leading to symptoms such as nystagmus, slurred speech, and decreased coordination. This toxicity is sometimes caused by drug interactions. Interactions between phenytoin and capecitabine are not commonly documented. We report...

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Detalles Bibliográficos
Autores principales: McGrath, Clare, Munro, Amy, Goel, Rakesh, Linden, Kelly, Dennis, Kristopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347445/
https://www.ncbi.nlm.nih.gov/pubmed/30697501
http://dx.doi.org/10.7759/cureus.3625
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author McGrath, Clare
Munro, Amy
Goel, Rakesh
Linden, Kelly
Dennis, Kristopher
author_facet McGrath, Clare
Munro, Amy
Goel, Rakesh
Linden, Kelly
Dennis, Kristopher
author_sort McGrath, Clare
collection PubMed
description Phenytoin toxicity occurs when serum levels exceed the therapeutic level, leading to symptoms such as nystagmus, slurred speech, and decreased coordination. This toxicity is sometimes caused by drug interactions. Interactions between phenytoin and capecitabine are not commonly documented. We report the case of a 52-year-old man taking phenytoin for atypical meningioma who developed symptoms of phenytoin toxicity while receiving capecitabine in the treatment of rectal adenocarcinoma.
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spelling pubmed-63474452019-01-29 Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction McGrath, Clare Munro, Amy Goel, Rakesh Linden, Kelly Dennis, Kristopher Cureus Neurology Phenytoin toxicity occurs when serum levels exceed the therapeutic level, leading to symptoms such as nystagmus, slurred speech, and decreased coordination. This toxicity is sometimes caused by drug interactions. Interactions between phenytoin and capecitabine are not commonly documented. We report the case of a 52-year-old man taking phenytoin for atypical meningioma who developed symptoms of phenytoin toxicity while receiving capecitabine in the treatment of rectal adenocarcinoma. Cureus 2018-11-23 /pmc/articles/PMC6347445/ /pubmed/30697501 http://dx.doi.org/10.7759/cureus.3625 Text en Copyright © 2018, McGrath et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
McGrath, Clare
Munro, Amy
Goel, Rakesh
Linden, Kelly
Dennis, Kristopher
Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction
title Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction
title_full Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction
title_fullStr Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction
title_full_unstemmed Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction
title_short Phenytoin Toxicity During Neoadjuvant Concurrent Capecitabine and Radiation Therapy for Rectal Adenocarcinoma: Case Report of a Drug Interaction
title_sort phenytoin toxicity during neoadjuvant concurrent capecitabine and radiation therapy for rectal adenocarcinoma: case report of a drug interaction
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347445/
https://www.ncbi.nlm.nih.gov/pubmed/30697501
http://dx.doi.org/10.7759/cureus.3625
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