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CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells

Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated i...

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Detalles Bibliográficos
Autores principales:	Silva-Pavez, Eduardo, Villar, Paulina, Trigo, César, Caamaño, Esteban, Niechi, Ignacio, Pérez, Pablo, Muñoz, Juan P., Aguayo, Francisco, Burzio, Verónica A., Varas-Godoy, Manuel, Castro, Ariel F., Colombo, María I., Tapia, Julio C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347595/ https://www.ncbi.nlm.nih.gov/pubmed/30683840 http://dx.doi.org/10.1038/s41419-019-1306-x

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