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Vitamin D therapy in children with inflammatory bowel disease: A systematic review

BACKGROUND: Vitamin D deficiency is highly prevalent in children with inflammatory bowel disease (IBD). This may contribute to an increased risk of poor bone health and may also influence the course of disease. An optimal treatment strategy of vitamin D therapy in children with IBD has not yet been...

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Autores principales: Rigterink, Tarah, Appleton, Laura, Day, Andrew S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347665/
https://www.ncbi.nlm.nih.gov/pubmed/30697514
http://dx.doi.org/10.5409/wjcp.v8.i1.1
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author Rigterink, Tarah
Appleton, Laura
Day, Andrew S
author_facet Rigterink, Tarah
Appleton, Laura
Day, Andrew S
author_sort Rigterink, Tarah
collection PubMed
description BACKGROUND: Vitamin D deficiency is highly prevalent in children with inflammatory bowel disease (IBD). This may contribute to an increased risk of poor bone health and may also influence the course of disease. An optimal treatment strategy of vitamin D therapy in children with IBD has not yet been established. AIM: To analyse the published intervention studies of vitamin D therapy in children with IBD. METHODS: A systematic review was conducted of clinical studies involving children with IBD (including Crohn disease or ulcerative colitis) who had received vitamin D therapy. Studies up to March 31(st) 2018 were identified through MEDLINE, PubMed, EMBASE and the Cochrane Library. Search terms included synonyms of the following terms: vitamin D, paediatric, supplementation, IBD. References of included articles based on abstract were searched for other relevant articles. All relevant articles were accessed and reviewed in full text. Studies fitting the set criteria were included and the remainder were excluded. RESULTS: Two hundred and seventy-seven discrete articles were identified. Following assessment of these articles included in the initial search and application of inclusion and exclusion criteria, ten published studies were included in this review. The included studies showed a heterogeneity in study design, inclusion and exclusion criteria, baseline demographics and treatment strategies. Treatment regimens differed in length, supplemented form of vitamin D and factors based upon which dosage was adjusted. Each of the reports included in this review concluded their vitamin D regimens to be safe and well-tolerated. Few of the included studies reported secondary outcomes on the efficacy of vitamin D treatment upon the clinical course of disease or markers of inflammation. The majority of included trials were not sufficient in raising serum vitamin D levels to an adequate level (30 ng/mL) in children with IBD with vitamin D deficiency. CONCLUSION: The included trials featured diverse treatment regimens that were predominantly insufficient in correcting vitamin D deficiency or maintaining adequate levels in children with IBD. Better treatment regimens are required for the management of vitamin D deficiency in children with IBD.
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spelling pubmed-63476652019-01-29 Vitamin D therapy in children with inflammatory bowel disease: A systematic review Rigterink, Tarah Appleton, Laura Day, Andrew S World J Clin Pediatr Systematic Reviews BACKGROUND: Vitamin D deficiency is highly prevalent in children with inflammatory bowel disease (IBD). This may contribute to an increased risk of poor bone health and may also influence the course of disease. An optimal treatment strategy of vitamin D therapy in children with IBD has not yet been established. AIM: To analyse the published intervention studies of vitamin D therapy in children with IBD. METHODS: A systematic review was conducted of clinical studies involving children with IBD (including Crohn disease or ulcerative colitis) who had received vitamin D therapy. Studies up to March 31(st) 2018 were identified through MEDLINE, PubMed, EMBASE and the Cochrane Library. Search terms included synonyms of the following terms: vitamin D, paediatric, supplementation, IBD. References of included articles based on abstract were searched for other relevant articles. All relevant articles were accessed and reviewed in full text. Studies fitting the set criteria were included and the remainder were excluded. RESULTS: Two hundred and seventy-seven discrete articles were identified. Following assessment of these articles included in the initial search and application of inclusion and exclusion criteria, ten published studies were included in this review. The included studies showed a heterogeneity in study design, inclusion and exclusion criteria, baseline demographics and treatment strategies. Treatment regimens differed in length, supplemented form of vitamin D and factors based upon which dosage was adjusted. Each of the reports included in this review concluded their vitamin D regimens to be safe and well-tolerated. Few of the included studies reported secondary outcomes on the efficacy of vitamin D treatment upon the clinical course of disease or markers of inflammation. The majority of included trials were not sufficient in raising serum vitamin D levels to an adequate level (30 ng/mL) in children with IBD with vitamin D deficiency. CONCLUSION: The included trials featured diverse treatment regimens that were predominantly insufficient in correcting vitamin D deficiency or maintaining adequate levels in children with IBD. Better treatment regimens are required for the management of vitamin D deficiency in children with IBD. Baishideng Publishing Group Inc 2019-01-22 /pmc/articles/PMC6347665/ /pubmed/30697514 http://dx.doi.org/10.5409/wjcp.v8.i1.1 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Systematic Reviews
Rigterink, Tarah
Appleton, Laura
Day, Andrew S
Vitamin D therapy in children with inflammatory bowel disease: A systematic review
title Vitamin D therapy in children with inflammatory bowel disease: A systematic review
title_full Vitamin D therapy in children with inflammatory bowel disease: A systematic review
title_fullStr Vitamin D therapy in children with inflammatory bowel disease: A systematic review
title_full_unstemmed Vitamin D therapy in children with inflammatory bowel disease: A systematic review
title_short Vitamin D therapy in children with inflammatory bowel disease: A systematic review
title_sort vitamin d therapy in children with inflammatory bowel disease: a systematic review
topic Systematic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347665/
https://www.ncbi.nlm.nih.gov/pubmed/30697514
http://dx.doi.org/10.5409/wjcp.v8.i1.1
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