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Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin

We report crystal structures of the antibacterial lasso peptides microcin J25 (MccJ25) and capistruin (Cap) bound to their natural enzymatic target, the bacterial RNA polymerase (RNAP). Both peptides bind within the RNAP secondary channel, through which NTP substrates enter the RNAP active site, and...

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Detalles Bibliográficos
Autores principales:	Braffman, Nathaniel R., Piscotta, Frank J., Hauver, Jesse, Campbell, Elizabeth A., Link, A. James, Darst, Seth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347699/ https://www.ncbi.nlm.nih.gov/pubmed/30626643 http://dx.doi.org/10.1073/pnas.1817352116

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