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Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation

BACKGROUND: Apolipoprotein E4 (APOE4) and ageing are the most important known risk factors for late-onset Alzheimer’s disease (AD). In the present study, we determined the alterations of IgG, CD19, and Aβ in various brain regions of uninfected male and female APOE3- and APOE4-TR mice at the age of 3...

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Detalles Bibliográficos
Autores principales:	Zhang, Lihang, Xu, Juan, Gao, Jinchao, Chen, Peiqing, Yin, Ming, Zhao, Wenjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347753/ https://www.ncbi.nlm.nih.gov/pubmed/30700991 http://dx.doi.org/10.1186/s12979-018-0142-7

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